Psychedelic Research Links February 2022

This is all the other psychedelic research that comes out in February 2022. These papers don’t (yet) have their own page in our database.

This page will be updated (almost) every day.

You can find all interesting papers in our Papers Database.

Related Papers

Use CTRL/CMD+F to quickly search if anything relevant for you has been published this month.

• mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression (secondary analysis)

• Development and application of a highly sensitive LC-MS/MS method for simultaneous quantification of N,N-dimethyltryptamine and two of its metabolites in human plasma (fully validated method for quantification of N,N-dimethyltryptamine and metabolites)

• Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice (rodent study, “all 5-HT2A receptor agonists elicited Gq-protein coupled and we find Gs protein may play a vital role in serotonergic hallucinogenic agonists”)

• Analysis of Psilocybin-Assisted Therapy in Medicine: A Narrative Review (review)

• Regulation of blood-brain barrier permeability by Salvinorin A via alleviating endoplasmic reticulum stress in brain endothelial cell after ischemia stroke (in vivo study)

• Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective? (review)

• Psychedelics hold promise for primary care research (review)

• Reconstituting the complete biosynthesis of D-lysergic acid in yeast (proof-of-concept approach for the synthesis of DLA from yeast)

• Development of an improved psilocybin synthesis (thesis)

• Caffeine and MDMA (Ecstasy) Exacerbate ER Stress Triggered by Hyperthermia (rodent study)

• Is approving esketamine as an antidepressant for treatment resistant depression associated with recreational use and risk perception of ketamine? Results from a longitudinal and cross-sectional survey in nightlife attendees (survey, n=2415, no change in recreational use of ketamine after esketamine approval)

• The therapeutic potential of psychedelic-assisted therapies for symptom control in patients diagnosed with serious illness: a systematic review (review, s=20, finds positive results for those with serious illness (e.g. improvements in end-of-life anxiety))

• Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development (deep dive into psilocybin-containing fungi)

• mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression (secondary analysis)

• Development and application of a highly sensitive LC-MS/MS method for simultaneous quantification of N,N-dimethyltryptamine and two of its metabolites in human plasma (fully validated method for quantification of N,N-dimethyltryptamine and metabolites)

• Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice (rodent study, “all 5-HT2A receptor agonists elicited Gq-protein coupled and we find Gs protein may play a vital role in serotonergic hallucinogenic agonists”)

• Analysis of Psilocybin-Assisted Therapy in Medicine: A Narrative Review (review)

• Regulation of blood-brain barrier permeability by Salvinorin A via alleviating endoplasmic reticulum stress in brain endothelial cell after ischemia stroke (in vivo study)

• Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective? (review)

• Psychedelics hold promise for primary care research (review)

• Reconstituting the complete biosynthesis of D-lysergic acid in yeast (proof-of-concept approach for the synthesis of DLA from yeast)

• Development of an improved psilocybin synthesis (thesis)

• Caffeine and MDMA (Ecstasy) Exacerbate ER Stress Triggered by Hyperthermia (rodent study)

• Is approving esketamine as an antidepressant for treatment resistant depression associated with recreational use and risk perception of ketamine? Results from a longitudinal and cross-sectional survey in nightlife attendees (survey, n=2415, no change in recreational use of ketamine after esketamine approval)

• The therapeutic potential of psychedelic-assisted therapies for symptom control in patients diagnosed with serious illness: a systematic review (review, s=20, finds positive results for those with serious illness (e.g. improvements in end-of-life anxiety))

• Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development (deep dive into psilocybin-containing fungi)

• Psilocybin: Characterization of the Metastable Zone Width (MSZW), Control of Anhydrous Polymorphs, and Particle Size Distribution (PSD) (more on the structure of psilocybin polymorphs – showing B forms independent of crystallization method, A under vacuum, A & H when heated)

• Consciousness is supported by near-critical slow cortical electrodynamics (interesting research into consciousness, “… we show that psychedelics may increase the information richness of cortical activity by tuning low-frequency cortical oscillations closer to this critical point.”)

• Psychedelics and schizophrenia: Distinct alterations to Bayesian inference (review, “we compare the changes in neural dynamics induced by LSD and ketamine (in healthy volunteers) against those associated with schizophrenia, as observed in resting-state M/EEG recordings”)

• Drug transporters ABCB1 (P-gp) and OATP, but not drug-metabolizing enzyme CYP3A4, affect the pharmacokinetics of the psychoactive alkaloid ibogaine and its metabolites (rodent study)

• N,N-dimethyltryptamine and Amazonian ayahuasca plant medicine (review)

• Esketamine nasal spray in patients with treatment-resistant depression: the real-world experience in the French cohort early-access programme (real-world data from a esketamine programe in France)

• The Effectiveness of Repeated Intravenous Ketamine on Subjective and Objective Psychosocial Function in Patients with Treatment-Resistant Depression and Suicidal Ideation (open-label, ketamine was associated with improvements in functional outcomes)

• Investigational drugs for assisting psychotherapy for posttraumatic stress disorder (PTSD): emerging approaches and shifting paradigms in the era of psychedelic medicine (Expert opinion on investigational drugs)

• Ayahuasca as a Decoction Applied to Human: Analytical Methods, Pharmacology and Potential Toxic Effects (review, the latest methods used in the analysis of the composition of ayahuasca and the analysis of various biological matrices)

• The promise of psychedelic research (review)

• Isotope fractionation during the synthesis of MDMA.HCl from helional (chemistry, isotope fractionation from the precursor helional)

• Neurotoxicological profile of the hallucinogenic compound 25I-NBOMe (in vivo toxicity of 25I-NBOMe)

• Ketamine Psychedelic and Antinociceptive Effects Are Connected (open-label, ketamine induces analgeisc like effects)

• DNA Authentication and Chemical Analysis of Psilocybe Mushrooms Reveal Widespread Taxonomic Misdeterminations and Inconsistencies in Metabolites (reveiw, chemistry and taxonomy of psilocybe mushrooms)

• Psychedelic Psychotherapy: Building Wholeness Through Connection (methodology, the paper outlines transformational psychotherapy, the therapeutic process and corresponding practice implications)

• Primitivist medicine and capitalist anxieties in ayahuasca tourism Peru (“the article explores a paradoxical aspect of ayahuasca tourism wherein guests purge similar anxious desires for capital accumulation that healers achieve when curing them“)

• Literary Theory on Acid (essay, “argues for the value of psychedelic experience as a framework for amplifying the social and political impacts of literature on the affective lives of readers and viewers“)

• Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1-42-Injected, Wild-Type Mouse Model of AD (rodent study, DMT and Alzheimers)

• The Role of Psychedelics in Managing Anxiety, Depression, and Flashbacks of Individuals with Post-Traumatic Stress Disorder (review)

• The effects of intranasal esketamine on on-road driving performance in patients with major depressive disorder or persistent depressive disorder (single bind, the effect of esketamine (84mg) on driving performance)

• Formal Total Synthesis of Salvinorin A (synthesis of salvia)

• Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice (rodent study)

• The therapeutic potential of psilocybin: a systematic review (review)

• Perceptual pathways to hallucinogenesis (theory-building, how can Bayesian inference models be used to discuss components that might lead to hallucinations)