Psychedelic Research Links May 2022

This is all the other psychedelic research that came out in May 2022. These papers don’t (yet) have their own page in our database.

You can find all interesting papers in our Papers Database.

Related Papers

• Virtual Daime: When Psychedelic Ritual Migrates Online (interviews, “this paper looks at this development and its repercussions for entheogenic rituals, as it asks how do psychedelic rituals change when they move online“)

• How Informed is the Informed Consent in Clinical Trials with Psychedelics? (thesis)

• Restorative Retelling for Processing Psychedelic Experiences: Rationale and Case Study of Complicated Grief (case study)

• Monoamine Oxidase Inhibition by Plant-Derived β-Carbolines; Implications for the Psychopharmacology of Tobacco and Ayahuasca (review)

• Lizard as a psychedelic fauna: a systematic review of published cases (case reports, n=8, consumption of lizards as psychedelics)

• Sex Differences in Central Amygdala Reactivity following psychedelic drug exposure (in mice!! showing differences between males and females after one dose of psilocybin (2mg/kg))

• Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration (in mice, similar mechanisms found also in humans “ LAT1, IDO1, NAD+, the nitric oxide (NO) signaling pathway, and sphingolipid rheostat.”)

• Potential advantages of ketamine over electroconvulsive therapy in the treatment of nonrefractory severe depression in older patients with multiple medical comorbidities (manuscript, case-based review)

• MDMA treatment paired with a trauma-cue promotes adaptive stress responses in a translational model of PTSD in rats (rodent study)

• The Cathinone Hydra: Increased Cathinone and caffeine adulteration in the English MDMA market after Brexit and COVID-19 lockdowns (analysis of MDMA at English music festivals in 2021 found that synthetic cathinones and caffeine each constituted approximately one-fifth of 2021 samples)

• Pharmacological Treatments for Anhedonia (review, mentions ketamine)

• The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol (review)

• Allosteric Binding of MDMA to the Human Serotonin Transporter (hSERT) via Ensemble Binding Space Analysis with ΔG Calculations, Induced Fit Docking and Monte Carlo Simulations (MDMA molecular mode of action)

• Temporal irreversibility of neural dynamics as a signature of consciousness (neuroimaging, “we implemented a data-driven deep learning framework to decode the temporal inversion of electrocorticography signals acquired from non-human primates“)

• The Pharmacology and Clinical Applications of Psychedelic Medicines Within Midwifery Practice (review)

• Sober sitter or coconsumer? Psychedelics, online forums and preferences for interpersonal interactions (review)

• Analytical profile, in vitro metabolism and behavioral properties of the lysergamide 1P-AL-LAD (characterization of a novel lysergamide)

• The crystal structure of baeocystin (chemistry, structure of the tryptamine baeocystin)

• A pilot psychedelic psychopharmacology elective (analysis of a new a psychedelic psychopharmacology elective)

• Manifest your desires: Psychedelics and the self-help industry (“we draw on some critiques of the self-help industry to propose potential parallels in the psychedelic industry“)

• Probing the antidepressant action of psychedelics (review)

• Psilocybe ningshanensis (Hymenogastraceae, Agaricales), a new species from China (new species of psilocybe mushroom)

• Grounded in Biology: Why the Context-Dependency of Psychedelic Drug Effects Means Opportunities, Not Problems for Anthropology and Pharmacology (opinion)

• Magic mushroom extracts in lipid membranes (“we compare the impact of the neutral and charged versions of psilocin and serotonin on the properties of zwitterionic and anionic lipid membranes using molecular dynamics simulations and calorimetry“)

• Toward a New Science of Psychedelic Social Psychology: The Effects of MDMA (Ecstasy) on Social Connection (opinion, “social psychologists have much to gain by incorporating psychoactive substances into their research programs“)

• A Hermeneutic Phenomenology of the N,N-Dimethyltryptamine (DMT) Experience (dissertation, describing the experience on low & high dose of DMT)

• Unusual attempted drug-facilitated sexual assault involving MDMA (French, case study, attempted date rape by dosing with MDMA)

• Psychedelics and Anti-inflammatory Activity in Animal Models (book chapter)

• Psychedelics in the Treatment of Headache and Chronic Pain Disorders (book chapter)

• Ecstasy-induced fixed drug eruption (case study, FDE – fixed drug eruption – skin reaction to drugs after MDMA use)

• Self-treatment of depression and complex post-traumatic stress disorder (C-PTSD) with psilocybin – a retrospective case study (case study)

• Paper-based monolith extraction of psychoactive substances from biological fluids (chemistry)

• Ketamine for Chronic Pain (review)

• Not Groovy Man: Psilocybin’s Long and Complicated History with the Law, and Its Potential to Treat the Growing Mental Health Crisis in America (review)

• 3,4-methylenedioxymethamphetamine (MDMA) stimulates activation of TAAR1 and subsequent neurotransmitter transporter internalization in serotonin neurons (rodent study)

• Safety considerations in the evolving legal landscape of psychedelic-assisted psychotherapy (“this piece seeks to clarify the special range of factors which ought to be considered to safely expand access to psychedelics“)

• Receptor binding profiles and behavioural effects of psilocybin analogues (chemistry)

• Asclepius Revisited—Ancient Myth and 21st-Century Psychedelic Medicine (essay, “the way psychedelic medicine is revitalizing and integrating analogues of these ancient practices into contemporary clinical care“)

• Psilocybin-induced takotsubo cardiomyopathy (case study)

• IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine (rodent study)

• Turn on, Tune in, Drop out? A Typology of Psychedelic Microdosing as Technologies of the Self (sociology)

• Views on Using Psychoactive Substances to Self-Manage Functional Neurological Disorder: Online Patient Survey Results (“An online survey was created to assess self-management strategies and views on novel treatments for FND, including psychedelic therapy“)

• Different symptomatic improvement pattern revealed by factor analysis between placebo response and response to Esketamine in treatment resistant depression (“data driven approach may provide detailed efficacy information in clinical trials for antidepressants“)

• Autophagy: a new mechanism for esketamine as a depression therapeutic (rodent study)

• A review on the mitochondrial toxicity of “ecstasy” (3,4-methylenedioxymethamphetamine, MDMA) (review, “in vitro and in vivo studies on MDMA mitochondria toxicity are revised“)

• Preliminary Results on the Long-Term Effects of Dextromethorphan on MDMA-Mediated Serotonergic Deficiency and Volumetric Changes in Primates Based on 4-[18F]-ADAM PET/MRI (primate study)

• Alternative Options for Complex, Recurrent Pain States Using Cannabinoids, Psilocybin, and Ketamine: A Narrative Review of Clinical Evidence (review)

• Genetic survey of Psilocybe natural products (genomic profile of five species of psilocybin mushrooms)

• Psychoactive Drugs in the Management of Post Traumatic Stress Disorder: A Promising New Horizon (review)

• Understanding brain states across spacetime informed by whole-brain modelling (review, “neuroimaging and whole-brain modelling motivating using mechanistic principles from dynamical system theory to study and characterize brain states“)

• An Overview on the Taxonomy, Phylogenetics and Ecology of the Psychedelic Genera Psilocybe, Panaeolus, Pluteus and Gymnopilus (review)

• New Paradigms of Old Psychedelics in Schizophrenia (theory, how can psychedelics be used to treat schizophrenia)

• Alternative Options for Complex, Recurrent Pain States Using Cannabinoids, Psilocybin, and Ketamine: A Narrative Review of Clinical Evidence (review)

• Physical Disability and Psychedelic Therapies: An Agenda for Inclusive Research and Practice (commentary)

• Systematic Review of Psychometric Instruments Used in Research with Psychedelics (review)

• Psychedelic Medicine: Creating an Introductory Course for Mental Health Professionals and Trainees (commentary)

• Psychedelic therapy for body dysmorphic disorder (opinion)

• Trust and Psychedelic Moral Enhancement (theory)

• R-(-)2,5-dimethoxy-4-iodoamphetamine (DOI) Blunts the Discriminative Stimulus Properties of Oxycodone (rodent study)

• Differential Regulation of Inflammatory Responses Following 5-HT2 Receptor Activation in Pulmonary Tissues (cell study)

• Understanding brain states across spacetime informed by whole-brain modelling (review)

• Can LSD be Associated with Chronic Exploding Head Syndrome? (case study)

• The 5-HT6R agonist E-6837 and the antagonist SB-271046 reverse the psychotic-like behaviors induced by ketamine (rodent study)

• The abuse liability of ketamine: A scoping review of preclinical and clinical studies (review)