In the Flinders Sensitive Line rat model of depression, psilocin and psilocybin produced no antidepressant-like effects in the forced swim test and did not alter locomotor activity, despite FSL rats showing the expected increased immobility versus controls. The authors suggest the FSL model and FST may be inappropriate for translational studies of psilocybin’s antidepressant actions.
- Published
- Journal
- Acta Neuropsychiatrica
- Authors
- Jefsen, O., Højgaard, K., Christiansen, S. L., Elfving, B., Nutt, D. J., Wegener, G., Müller, H. K.