Following oral administration of 100 μg LSD to 20 healthy participants, resting‑state fMRI showed increased thalamic functional connectivity to multiple cortical regions, with thalamus–right fusiform and thalamus–insula connectivity correlating with subjective visual and auditory effects. These findings suggest enhanced thalamocortical coupling—likely via 5‑HT2A receptor mechanisms—may underlie LSD‑induced hallucinations by facilitating cortical excitability.
- Published
- Journal
- Acta Psychiatrica Scandinavica
- Authors
- Lenz, C., Dolder, P. C., Lang, U. E., Schmidt, A., Liechti, M. E., Borgwardt, S., Mueller, F.