Using individualised whole‑brain computational modelling fitted to fMRI and diffusion MRI, the authors simulated administration of LSD and psilocybin and applied in silico perturbations to compare states of consciousness and assess treatment effects in disorders of consciousness. Simulated psychedelics shifted patients' brain dynamics closer to criticality—especially in the minimally conscious state—with responses in UWS linked to structural connectivity and in MCS to baseline functional connectivity, providing a computational rationale for psychedelic therapies and personalised prediction.
- Published
- Journal
- Advanced Science
- Authors
- Alnagger, N. L., Cardone, P., Martial, C., Perl, Y. S., Mindlin, I., Sitt, J. D., Roseman, L., Carhart‐Harris, R., Nutt, D., Mallaroni, P., Mason, N., Ramaekers, J. G., Bonhomme, V., Laureys, S., Deco, G., Gosseries, O., Núñez, P., Annen, J.