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Academic Journal

American Academy of Clinical Psychiatrists

2 Papers Indexed in Blossom

Published Papers

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Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition

This open-label study (n=25) explored the effects of using intravenous ketamine to treat treatment-resistant depression (TRD) in participants over the age of 60. Depressive symptoms improved significantly, 48% of participants responded, and during the acute phase, executive function measures and the fluid cognition composite score improved (Cohen's d = 0.61).

Published
Journal
American Academy of Clinical Psychiatrists
Authors
Oughli, H. A., Gebara, M. A., Ciarleglio, A., Lavretsky, H., Brown, P. J., Flint, A. J., Farber, N. B., Karp, J. F., Mulsant, B. H., Reynolds, C. F., Roose, S. P., Yang, L., Butters, M. A., Lenze, E. J.
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High-dose ketamine infusion for the treatment of posttraumatic stress disorder in combat veterans.

In an observational study of 30 combat veterans, six high‑dose 1‑hour ketamine infusions targeting a transpersonal dissociative experience produced large, statistically significant reductions in depressive (PHQ mean 18.9→9.5) and PTSD symptoms (PCL‑5 mean 56.2→31.3), while self‑reported substance use did not significantly change. These results suggest high‑dose ketamine infusion therapy may be a promising treatment for combat‑related PTSD and warrant controlled trials to confirm efficacy and clarify mechanisms.

Published
Journal
American Academy of Clinical Psychiatrists
Authors
Ross, C., Jain, R., Bonnett, C. J., Wolfson, P. E.

Quick Facts

Papers Indexed
2
h-Index
79
Publisher
American Psychiatric Association
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