This mouse study investigated the effects of the highly selective 5-HT₂ receptor agonist (R)-DOI (0.01-1mg/kg) in a mouse model of allergic asthma. They demonstrate that inhaled (R)-DOI has potent anti-inflammatory effects and blocks the development of allergic asthma through the activation of the serotonin 5-HT2A receptor subtype.
- Published
- Journal
- American Journal of Physiology
- Authors
- Nau, F., Miller, J., Saravia, J., Ahlert, T., Yu, B., Happel, K. I., Cormier, S. A., Nichols, C. D.