Asia Pacific Journal of Clinical Trials Nervous System Diseases

Trauma Interventions using Mindfulness Based Extinction and Reconsolidation (TIMBER) psychotherapy prolong the therapeutic effects of single ketamine infusion on post-traumatic stress disorder and comorbid depression: a pilot randomized, placebo-controlled, crossover clinical trial

This randomised, placebo-controlled, cross-over clinical pilot study (n=10) investigated the antidepressant efficacy of ketamine (35mg/70kg) infusion combined with Mindfulness Based Extinction and Reconsolidation (TIMBER) psychotherapy for patients with PTSD. Ketamine-assisted TIMBER therapy increased the duration of the sustained antidepressant response, as evidenced by improvement of depressive symptoms after switching from the placebo into ketamine condition.

Published

January 1, 2017

Journal

Asia Pacific Journal of Clinical Trials Nervous System Diseases

Authors

Pradhan, B. K., Wainer, I. W., Moaddel, R., Torjman, M. C., Goldberg, M., Sabia, M., Parikh, T., Pumariega, A. J.