This analysis of fMRI data (n=15) examined how LSD (75μg) affects local brain activity and connectivity, finding that LSD decreased both measures in somatosensory/visual areas, with additional activity decreases in Default Mode and Fronto-Parietal networks and connectivity decreases in subcortical regions, with these changes occurring primarily in brain regions with high densities of D2 and 5HT1a receptors, suggesting complex neurobiological mechanisms underlying LSD's effects.
- Published
- Journal
- Authorea
- Authors
- La-Torraca-Vittori, P., Tarchi, L., Arrigo, E., Lanterna, S., Tosi, E., Doose, A., Palesi, F., Pischedda, D., Ricca, V., Fusar-Poli, P., Damiani, S.