This mouse study investigated the effects of ayahuasca (35.2 µg DMT) on alcohol withdrawal in mice and found that it exerted an anxiolytic effect and attenuated the behavioral sensitization to alcohol. Furthermore, it prevented alcohol-induced changes on 5-HT1a receptor and prodynorphin levels in the hippocampus and reduced ethanol effects in the dynorphin/prodynorphin in the striatum.
- Published
- Journal
- Behavioural Brain Research
- Authors
- Almeida, C. A. F., Pereira, B. P., Pereira Junior, A. A., Rangel, J. G., Costa, K. C. M., Bruno, V., Silveira, G. O., Ceron, C. S., Yonamine, M., Camarini, R., Garcia, R. C. T., Marcourakis, T., Torres, L. H.