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Academic Journal

Bipolar Disorders

3 Papers Indexed in Blossom

Published Papers

Paywallindividual

Real World Effectiveness of Repeated Ketamine Infusions for Treatment Resistant Bipolar Depression

In a real‑world observational cohort of 66 patients with treatment‑resistant bipolar I/II depression, four sub‑anaesthetic intravenous ketamine infusions over two weeks produced statistically and clinically significant, progressive reductions in depressive symptoms, suicidality and anxiety (mean QIDS‑SR16 reduction 6.08; p<0.0001). Response and remission rates were 35% and 20% respectively, with generally good tolerability (4.5% treatment‑emergent hypomania, no mania or psychosis).

Published
Journal
Bipolar Disorders
Authors
Fancy, F., Rodrigues, N. B., Di Vincenzo, J. D., Chau, E. H., Sethi, A., Husain, M. I., Gill, H., Tabassum, A., Mckenzie, A., Phan, L., McIntyre, R. S., Rosenblat, J. D.
Open Accessindividual

Ketamine versus midazolam in bipolar depression with suicidal thoughts: A pilot midazolam-controlled randomized clinical trial

In a pilot randomised, midazolam‑controlled trial of 16 people with bipolar depression and suicidal ideation, a single sub‑anaesthetic ketamine infusion produced a larger reduction in suicidal ideation at day 1 than midazolam (mean difference ≈5.8 points, P=0.074), demonstrating feasibility and preliminary efficacy. Memory improvement on the Selective Reminding Test and reductions in serum BDNF correlated with suicidal‑ideation decreases after ketamine, but the findings require replication in a fully powered trial.

Published
Journal
Bipolar Disorders
Authors
Grunebaum, M. F., Ellis, S. P., Keilp, J. G., Moitra, V. K., Cooper, T. B., Marver, J. E., Burke, A. K., Milak, M. S., Sublette, |. M. E., Oquendo, M. A., Mann, |. J. J.
Open Accessindividual

A single infusion of ketamine improves depression scores in patients with anxious bipolar depression

In a post‑hoc analysis of 36 treatment‑resistant bipolar depressed patients (on lithium or valproate), a single 0.5 mg/kg ketamine infusion produced significant antidepressant effects on MADRS and HDRS through 14 days in both anxious and non‑anxious subgroups, with no evidence that baseline anxiety reduced ketamine’s efficacy.

Published
Journal
Bipolar Disorders
Authors
Ionescu, D. F., Luckenbaugh, D. A., Niciu, M. J., Richards, E. M., Zarate, C. A.

Quick Facts

Papers Indexed
3
h-Index
145
Open Access
No
Publisher
Wiley
Country
Denmark
Website
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