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BJPsych Open

4 Papers Indexed in Blossom

Published Papers

Open Accessmeta

Psychedelics in NHS services: exploring a model for real-world implementation of psilocybin

This commentary (2026) discusses how psilocybin could be delivered in publicly funded health services such as the NHS, focusing on the role of psychological support alongside the drug. It outlines a possible service model and emphasises that implementation should be grounded in strong evidence and equitable access.

Published
Journal
BJPsych Open
Authors
Smith, K. A., Harcourt, E., Cipriani, A.
Open Accessindividual

LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up

In a planned 12‑month open‑label follow‑up of a double‑blind, placebo‑controlled crossover trial, LSD‑assisted therapy produced sustained, clinically significant reductions in anxiety and depression with large effect sizes lasting up to nearly two years after treatment. Participants also showed decreased neuroticism, increased extraversion and reported positive long‑term effects attributed to the psychedelic experience.

Published
Journal
BJPsych Open
Authors
Holze, F., Gasser, P., Müller, F., Strebel, M., Liechti, M. E.
Open Accessindividual

Effects of psilocybin versus escitalopram on rumination and thought suppression in depression

In a randomised trial of 59 patients with major depressive disorder, psilocybin (COMP360) but not escitalopram produced significant reductions in rumination and thought suppression over 6 weeks; decreased thought suppression was specific to psilocybin responders while rumination fell in responders to both treatments. Reductions in both measures in the psilocybin arm correlated with ego dissolution and session-linked psychological insight, suggesting these processes may mediate its antidepressant effects.

Published
Journal
BJPsych Open
Authors
Barba, T., Buehler, S., Kettner, H., Radu, C., Cunha, G., Nutt, D. J., Erritzoe, D., Roseman, L., Carhart-Harris, R. L.
Open Accessindividual

Ketamine treatment for individuals with treatment-resistant depression: longitudinal qualitative interview study of patient experiences

In a longitudinal qualitative study of 12 patients with treatment-resistant depression, ketamine typically produced short-term improvements in mood and reductions in suicidal ideation, but benefits were transient for most and some experienced increased hopelessness and suicidality as effects wore off. Participants also reported side-effects and cost concerns, prompting recommendations for closer monitoring, adjunctive psychological therapy and explicit informed consent about relapse and potential worsening of suicidality.

Published
Journal
BJPsych Open
Authors
Lascelles, K., Marzano, L., Brand, F., Trueman, H., Mcshane, R., Hawton, K.

Quick Facts

Papers Indexed
4
h-Index
50
Open Access
Yes
Publisher
Cambridge University Press
Country
United Kingdom
Website
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