In a randomised, placebo-controlled trial of 80 healthy men given 10 µg LSD every third day for six weeks, standard ERP peak analyses showed no acute or cumulative effects on visually induced long-term potentiation. Dynamic causal modelling with a thalamo-cortical model, however, revealed laminar-specific changes in excitatory and inhibitory connectivity in primary visual cortex, suggesting the modelling approach is more sensitive than classic ERP measures for detecting microdose-induced plasticity.
- Published
- Journal
- BMC Psychiatry
- Authors
- Godfrey, K., Murphy, R. J., Muthukumaraswamy, S., Shaw, A. D., Sumner, R. L.