This theory-building paper (2021) presents a new model of how psychedelic drugs may act in the brain. The new model, the cortico-clasustro-cortical model (CCC model), proposes that psychedelics disrupt 5-HT2A-mediated network coupling between the claustrum (a region of the brain where 5-HT2A receptors are densely expressed) and the cortex, leading to attenuation of canonical cortical networks. This model is discussed in relation to two previously described models, the CSTC and REBUS.
- Published
- Journal
- Brain
- Authors
- Barrett, F. S., Doss, M. K., Gaddis, A., Griffiths, R. R., Madden, M. B., Mathur, B. N., Nebel, M. B.