The paper proposes a continuum hypothesis that psychotomimetic rapid antidepressants (ketamine, classical psychedelics and sleep deprivation) produce acute antidepressant effects by increasing the flexibility of prior expectations within a hierarchical predictive coding framework, thereby linking their antidepressant and psychotomimetic actions. It reviews supporting neurobiological and neuromodulatory evidence, contrasts the idea with other antidepressant theories, and proposes experiments to test the hypothesis.
- Published
- Journal
- Brain and Neuroscience Advances
- Authors
- Haarsma, J., Harmer, C. J., Tamm, S.