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brazilian Journal of Psychiatry

7 Papers Indexed in Blossom

Published Papers

Paywallindividual

Low-dose ketamine does not improve the speed of recovery from depression in electroconvulsive therapy: a randomized controlled trial

This randomised, double-blind, placebo-controlled study investigated the efficacy of using low-dose ketamine (35mg/70kg) as an anaesthetic adjunct to propofol during electroconvulsive therapy (ECT) for treating patients with depression (MDD). Adding ketamine did not alter the antidepressant efficacy or the hemodynamics of electroconvulsive therapy, although it may help reduce the dose requirements of propofol anaesthesia.

Published
Journal
brazilian Journal of Psychiatry
Authors
Woolsey, A. J., Nanji, J. A., Moreau, C., Sivapalan, S., Bourque, S. L., Ceccherini-Nelli, A., Gragasin, F. S.
Open Accessindividual

Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial

This double-blind placebo-controlled between-subjects study (n=23) tested the antidepressant efficacy of inhaled nitrous oxide (50% N2O|50% O2 versus 100% O2) in patients diagnosed with major depression (MDD). Across multiple treatment sessions administered across a period of 4 weeks, there were significant reductions in depressive symptoms in the acute response to treatment and accumulatively across sessions.

Published
Journal
brazilian Journal of Psychiatry
Authors
Guimarães, M. C., Guimarães, T. M., Hallak, J. E., Abrão, J., Machado-de-Sousa, J. P.
Open Accessindividual

3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil

This open-label clinical pilot study (n=3) investigated the efficacy of MDMA-assisted psychotherapy (75 mg in the 1st session, 75 or 125 mg in the 2nd and 3rd sessions) for patients suffering from severe post-traumatic stress disorder due to sexual abuse. One showed small but clinically significant improvement, one showed moderate improvement, and one showed strong improvement, with regard to diagnostic symptoms for PTSD.

Published
Journal
brazilian Journal of Psychiatry
Authors
Jardim, A. V., Jardim, D. V., Chaves, B. D. R., Steglich, M., Ot’alora G, M., Mithoefer, M. C., da Silveira, D. X., Tófoli, L.F., Ribeiro, S., Doblin, R., Schenberg, E. E.
Open Accessindividual

Acute effects of ayahuasca in a juvenile non-human primate model of depression

This animal study (n=15) investigated the efficacy of ayahuasca (0.6mg DMT, 3.1mg harmine, 0.4mg harmaline, and 0.34mg tetrahydroharmine /300g) to treat depressed marmoset monkeys exposed to 8 weeks of social isolation. They found that ayahuasca reduced scratching and depression-like behaviors, increased the feeding rate, and restored body weight and fecal cortisol to baseline levels, particularly within male monkeys.

Published
Journal
brazilian Journal of Psychiatry
Authors
da Silva, F. S., Galvão-Coelho, N. L.
Open Accessmeta

Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies

This review (2016) examines studies on the mental health effects of ayahuasca, harmine, and harmaline within humans and animals, and shows consistent evidence for its antidepressant and anxiolytic (anxiety) effects.

Published
Journal
brazilian Journal of Psychiatry
Authors
Dos Santos, R. G., Osório, F. L., Crippa, J. A., Hallak, J. E.
Open Accessmeta

Oral ketamine for the treatment of pain and treatment-resistant depression

This systematic review (2016; s=88) examined the efficacy and safety of various ketamine administration routes for depression and chronic pain. It concludes that while intravenous studies show short-term success, oral ketamine appears well-tolerated in pain management settings, suggesting potential utility for the longer-term treatment of treatment-resistant depression.

Published
Journal
brazilian Journal of Psychiatry
Authors
Schoevers, R. A., Chaves, T. V., Balukova, S. M., Kortekaas, R.

Quick Facts

Papers Indexed
7
h-Index
72
Publisher
Associação Brasileira de Psiquiatria
Website
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