Renal ischaemia–reperfusion in rats causes metabolic disturbance (raised lactate, acidosis) and adverse micro-rheological changes (increased erythrocyte aggregation, reduced deformability). Pre‑treatment with the sigma‑1 receptor agonist N,N‑dimethyltryptamine attenuated but did not fully prevent these metabolic and micro‑rheological alterations.
- Published
- Journal
- Clinical Hemorheology and Microcirculation
- Authors
- Peto, K., Nemeth, N., Mester, A., Magyar, Z., Ghanem, S., Somogyi, V., Tanczos, B., Deak, A., Bidiga, L., Frecska, E., Nemes, B.