In a double‑blind, placebo‑controlled, randomised crossover trial of 15 healthy adults, a single 100 mg oral dose of MDMA acutely and robustly activated the HPA axis, producing significant increases in plasma ACTH and cortisol. Together with its known effect on oxytocin, this suggests MDMA could serve as a novel simultaneous stimulation test for oxytocin and HPA axis function, pending validation in larger studies.
- Published
- Journal
- Endocrine Connections
- Authors
- Atila, C., Camerin, S.-J., Liechti, M. E., Christ-Crain, M.