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European Archives of Psychiatry and Clinical Neuroscience

5 Papers Indexed in Blossom

Published Papers

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Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users

This observational, cross-sectional study (n=48) investigates the influence of ritualistic ayahuasca consumption on cognition among experienced (n=16) and beginner (n=16) ayahuasca users and a control group (n=16). It finds no evidence of cognitive decline among ayahuasca users, with experienced users showing higher scores in tasks assessing working verbal and visuospatial memories compared to beginners.

Published
Journal
European Archives of Psychiatry and Clinical Neuroscience
Authors
Fonseca, A. M., Dos Santos, R. G., Santos, F. P., de Medeiros, L. S., Veiga, T. A. M., Cassas, F., Bruniera, C. P., Rossi, G. N., Bouso, J. C., Hallak, J. E., Paranhos, B. A. P. B., Yonamine, M., Rodrigues, E.
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The correlation of Esketamine with specific adverse events: a deep dive into the FAERS database

This retrospective analysis (n=5061) of FAERS data on esketamine from 2019 to 2023 reveals 117 adverse reactions. In addition to known adverse events, new signals like flashback, tachyphylaxis, and autoscopy were identified. Suicidal ideation and attempts were relatively high, emphasizing the need for vigilance, while issues related to nasal administration, such as monitoring procedure errors and discomfort, were highlighted.

Published
Journal
European Archives of Psychiatry and Clinical Neuroscience
Authors
Jiang, Y., Du, Z., Shen, Y., Zhou, Q., Zhu, H.
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The effects of ketamine and classic hallucinogens on neurotrophic and inflammatory markers in unipolar treatment-resistant depression: a systematic review of clinical trials

This systematic review (2022, s=12) finds inconclusive results for the effects of psychedelics on several biomarkers (neurotrophic & inflammatory) in studies that used ayahuasca and ketamine in treating 'treatment-resistant' depression. Bigger trials are necessary, though studying the biomarkers per drug (not several together) may also be warranted.

Published
Journal
European Archives of Psychiatry and Clinical Neuroscience
Authors
Rossi, G. N., Hallak, J. E., Baker, G., Dursun, S., Dos Santos, R. G., Aaru, J.
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Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016-2020) systematic review of preclinical and human studies

This review (2021; s=9) of ayahuasca for substance use disorders (SUDs; e.g. alcoholism) found improvements in both rodents and humans who were suffering from SUDs (also on scores of anxiety and depression). The human studies were observational (vs RCTs) thus lacking the power to (confidently) infer causality.

Published
Journal
European Archives of Psychiatry and Clinical Neuroscience
Authors
Rodrigues, L. S., Rossi, G. N., Rocha, J. M., Osório, F. L., Bouso, J. C., Hallak, J. E., Dos Santos, R. G.
Open Accessindividual

Intravenous arketamine for treatment-resistant depression: open-label pilot study

This open-label study (n=7) study investigated the antidepressant efficacy of (R-)ketamine (35mg/70kg), which has been implicated by animal studies to be more potent and longer-lasting compared to (S-)ketamine. Results demonstrate (R-)ketamine's ability to produce a fast and robust antidepressant effect in patients with depression, with potentially greater and longer-lasting effects, greater response rate, and a lower remission rate than effects reported for (S-)ketamine, although this study had a small sample size and lacked placebo-control.

Published
Journal
European Archives of Psychiatry and Clinical Neuroscience
Authors
Leal, G. C., Bandeira, I. D., Correia-Melo, F. S., Telles, M., Mello, R. P., Vieira, F., Lima, C. S., Paula, A., Guerreiro-Costa, L. N. F., Marback, R. F., Caliman-Fontes, A. T., Marques, B. L. S., Bezerra, M. L. O., Dias-Neto, A. L., Silva, S. S., Sampaio, A. S., Sanacora, G., Turecki, G., Loo, C., Lacerda, A. L. T., Quarantini, L. C., Hashimoto, K.

Quick Facts

Papers Indexed
5
h-Index
114
Open Access
No
Publisher
Springer Nature
Country
Germany
Website
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