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Academic Journal

European Journal of Pharmacology

3 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT)

This paper outlines the formulation development, in vitro, and in vivo testing of transdermal drug-in-adhesive DMT patches using various adhesives and permeation enhancers. In vivo behavioural and pharmacokinetic studies performed with lead patch formulation (F5) in male and female Swiss Webster mice showed that transdermal administration provided consistent, extended drug release at a non-hallucinogenic dose, with a 77% bioavailability compared to IV at two dosages.

Published
Journal
European Journal of Pharmacology
Authors
Witowski, C. G., Hess, M. R., Jones, N. T., Hahn, M. C. P., Razidlo, J., Bhavsar, R., Beer, C., Gonzalez-Velazquez, N., Scarlett, C. O., Wenthur, C. J., Von Salm, J. L.
Open Accessindividual

Pharmacokinetics of N,N-dimethyltryptamine in Humans

This Phase I study provides the first detailed human pharmacokinetic characterisation of intravenous DMT fumarate (SPL026), demonstrating dose‑proportional exposure across 9–21.5 mg, rapid peak plasma concentrations (~10 min), a short elimination half‑life (9–12 min), ~70% unbound fraction and good tolerability. In vitro data indicate mitochondrial MAO‑A‑mediated metabolism with modulation by CYP2D6 and CYP2C19, supporting the design of DMT infusion regimens for major depressive disorder.

Published
Journal
European Journal of Pharmacology
Authors
Good, M., Joel, Z., Benway, T., Routledge, C., Timmermann, C., Erritzoe, D., Weaver, R., Allen, G., Hughes, C., Topping, H., Bowman, A., James, E.
Paywallindividual

Inhibitory effects of ibogaine on cocaine self-administration in rats

This rat study (n=56) examined the effects of single and repeated injections of ibogaine (40 mg/kg) on the cocaine self-administration model in rats and found that it inhibited addictive behaviors for 1-2 days or longer with additional weekly injections, even when ibogaine levels in the body were undetectable.

Published
Journal
European Journal of Pharmacology
Authors
Cappendijk, S. L. T., Dzoljic, M. R.

Quick Facts

Papers Indexed
3
h-Index
210
Open Access
No
Publisher
Elsevier
Country
Netherlands
Website
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