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Frontiers in Behavioural Neuroscience

3 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior

This primate study (n=12) found that ayahuasca (at 3 points in time) led to better resilience to being separated from the family groups. The animals that had received ayahuasca (n=6) showed no indication of anhedonia (inability to feel pleasure) and showed higher cortisol reactivity (positive).

Published
Journal
Frontiers in Behavioural Neuroscience
Authors
Galvão-Coelho, N. L., De Meiroz Grilo, M. L. P., de Sousa, G. M., de Sousa, M. B. C., Lobão-Soares, B., Palhano-Fontes, F., de Araujo, D. B., Perkins, D., Hallak, J. E., de Mendoça, L. A. C.
Open Accessindividual

The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement

This rodent study (2022) assessed the extent to which drugs that increase synaptic dopamine, norepinephrine, and serotonin enhance the positive reinforcing effects of social contact. Rats were given doses of a selective dopamine reuptake inhibitor, a selective norepinephrine reuptake inhibitor, a selective serotonin reuptake inhibitor, cocaine, d-amphetamine and MDMA. It was found that increases in extracellular dopamine, but not extracellular norepinephrine or serotonin, increase the positive reinforcing effects of social contact.

Published
Journal
Frontiers in Behavioural Neuroscience
Authors
Sharp, J. L., Smith, M. A.
Open Accessindividual

Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats

This rodent study (2021) assessed whether if female rats escalate self-administration of the entactogens MDMA, methylone and pentylone, and investigated the impact this has on GABAA receptor and kappa-opioid receptor (KOR) signalling in the amygdala. It was found that GABA transmission increased in pentylone and MDMA rats compared to those administered saline while pentylone and MDMA disrupted KOR signalling. These findings suggest that GABA and KOR mechanisms play a critical role in entactogen self-administration like those observed with escalation of alcohol or cocaine self-administration.

Published
Journal
Frontiers in Behavioural Neuroscience
Authors
Tejeda, H., Roberto, M., Taffe, M. A., Khom, S., Nguyen, J. D., Vandewater, S. A., Grant, Y.

Quick Facts

Papers Indexed
3
Publisher
Frontiers Media
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