Using [11C]MDL 100,907 PET and resting‑state fMRI‑derived cortical parcellation in four healthy volunteers, a single oral psychoactive dose of psilocybin produced mean cortical 5‑HT2A receptor occupancy of 39.5% (±10.9%), with the highest occupancy (63–75%) in default mode network regions (subgenual anterior cingulate and bilateral angular gyri). Significant inter‑individual variability was observed, supporting further study of how regional 5‑HT2A occupancy relates to acute and lasting effects of psilocybin.
- Published
- Journal
- Frontiers in Neuroergonomics
- Authors
- Barrett, F. S., Zhou, Y., Carbonaro, T. M., Roberts, J. M., Smith, G. S., Griffiths, R. R., Wong, D. F.