Using in vitro receptor profiling and rat RNA‑seq, the authors show methylone is a monoamine uptake inhibitor/releaser that rapidly upregulates neuroplasticity‑related genes in frontal cortex and regulates myelin‑related genes in the amygdala. Unlike MDMA, methylone showed no off‑target activity across 168 GPCRs, indicating greater specificity and supporting its potential as a PTSD treatment.
- Published
- Journal
- Frontiers in Neuroscience
- Authors
- Schmidt, E. F., Warner-Schmidt, J., Stogniew, M., Mandell, B., Rowland, R. S., Kelmendi, B.