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Frontiers in Pain Research

2 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: An open-label, proof-of-concept clinical trial

In an open-label proof-of-concept trial (N=5), psilocybin-assisted therapy was well tolerated in adults with fibromyalgia, producing only transient elevations in blood pressure/heart rate and non-serious post-dose headaches. Participants showed clinically meaningful improvements in pain severity, pain interference and sleep disturbance one month after treatment, supporting progression to larger randomised controlled trials.

Published
Journal
Frontiers in Pain Research
Authors
Aday, J. S., Mcafee, J., Conroy, D. A., Hosanagar, A., Tarnal, V., Weston, C., Scott, K., Horowitz, D., Harte, S. E., Pouyan, N., Glynos, N. G., Baker, A. K., Guss, J., Davis, A. K., Burgess, H. J., Mashour, G. A., Clauw, D. J., Boehnke, K. F.
Open Accessindividual

Ketamine-assisted psychotherapy treatment of chronic pain and comorbid depression: a pilot study of two approaches

This observational pilot of ten people with chronic pain and comorbid major depressive disorder compared a high‑dose intramuscular "psychedelic" KAPT protocol with a low‑dose sublingual "psycholytic" protocol and found reductions in depression, pain, anxiety and PTSD symptoms overall, with larger and more consistent decreases in the psychedelic group though differences were not statistically significant given the small sample. The authors conclude KAPT may be beneficial for chronic pain/MDD comorbidity and recommend larger controlled trials to determine optimal dosing and administration.

Published
Journal
Frontiers in Pain Research
Authors
Batievsky, D., Weiner, M., Kaplan, S. B., Thase, M., Maglione, D. N., Vidot, D. C.

Quick Facts

Papers Indexed
2
h-Index
20
Open Access
Yes
Publisher
Frontiers Media
Country
Switzerland
Website
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