In a double‑blind, placebo‑controlled crossover study in 16 healthy volunteers, a single 200 μg dose of LSD produced significant acute increases in circulating glucocorticoids (cortisol, cortisone, corticosterone and 11‑dehydrocorticosterone) and dehydroepiandrosterone. These steroid rises were temporally correlated with plasma LSD concentrations and peak psychedelic effects, with no evidence of acute pharmacological tolerance.
- Published
- Journal
- Journal of Neuroendocrinology
- Authors
- Dolder, P. C., Kratschmar, D. V., Liechti, M. E., Odermatt, A., Rentsch, K. M., Schmid, Y., Strajhar, P.