In a randomised, crossover, placebo‑controlled study of healthy adults, a single low dose (20 mg) of ketamine reduced pain perception and attenuated mean blood pressure responses to a cold pressor test but did not change muscle sympathetic nerve activity burst frequency. This dissociation suggests ketamine lowers pressor responses via mechanisms other than suppression of MSNA, informing clinical risk–benefit considerations.
- Published
- Journal
- Journal of Physiology
- Authors
- Watso, J. C., Huang, M., Moralez, G., Cramer, M. N., Hendrix, J. M., Cimino III, F. A., Belval, L. N., Hinojosa-Laborde, C., Crandall, C. G.