The authors introduce HADES, a Harmonic Decomposition of Spacetime framework that quantifies how spatial harmonic brain modes are expressed over time, and apply it to show that DMT reduces contributions of most low‑frequency harmonics and specifically diminishes the second functional harmonic linked to the uni‑to‑transmodal functional hierarchy. Dynamic spacetime measures (fractional occupancy, lifetime and latent space) further delineate the hierarchical reorganisation of brain activity in the psychedelic state.
- Published
- Journal
- National Science Review
- Authors
- Vohryzek, J., Cabral, J., Timmermann, C., Atasoy, S., Roseman, L., Nutt, D. J., Carhart-Harris, R. L., Deco, G., Kringelbach, M. L.