Academic Journal

Nature

10 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Psychedelics reopen the social reward learning critical period

This mice study shows that psychedelics (including ketamine & MDMA) open a social reward learning critical period. The duration of the drugs' effects in humans is proportional to the time it takes for the critical period to reopen. Additionally, the restoration of oxytocin-mediated long-term depression in the nucleus accumbens is associated with the reinstatement of social reward learning in adulthood. The study also found that reorganising the extracellular matrix is a common mechanism underlying the critical period reopening caused by psychedelic drugs.

Published
Journal
Nature
Authors
de Deus, J. L., Dölen, G., Faltin, S., Goff, L. A., Lama, C., Nardou, R., Padovan-Hernandez, Y., Sawyer, E., Song, Y. J., Stein-O'Brien, G. L., Wilkinson, M., Wright, N.
Open Accessindividual

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

This chemistry paper (2022) simulates the docking of 75 million molecules (tetrahydropyridines, THP) on the serotonin 2a (5-HT2a) receptor. The initial screening led to 17 molecules that were further refined down to two molecules ((R)-69 & (R)-70). These two had antidepressant effects (in mice) but didn't show (acute) psychoactive activity (head-twitch response, change in movement).

Published
Journal
Nature
Authors
Barros-Álvarez, X., Che, T., Confair, D. N., DiBerto, J. F., Ellman, J. A., Huang, X., Irwin, J. J., Kamber, D. N., Kaplan, A. L., Kim, K., Kumar, J. M., Kweon, O. S., Martins, L. C., McCorvy, J. D., Panova, O., Phelan, J. P., Pogorelov, V. M., Robertson, M. J., Rodriguiz, R. M., Roth, B. L., Seven, A. B., Shoichet, B. K., Skiniotis, G., Slocum, S. T., Wetsel, A. Q., Wetsel, W. C., Yang, Y.

Quick Facts

Papers Indexed
10
h-Index
1442
Open Access
No
Publisher
Springer Nature
Country
United Kingdom
Website
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