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Nature Neuroscience

2 Papers Indexed in Blossom

Published Papers

Paywallindividual

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

This rodent study found that the nonhallucinogenic psychoplastogen tabernanthalog (TBG) promotes cortical neuroplasticity and sustained antidepressant effects through the same 5-HT2A, TrkB, mTOR, and AMPA receptor pathway as psychedelics, but without inducing the immediate glutamate burst or immediate early gene activation previously thought necessary for psychedelic-induced neuroplasticity.

Published
Journal
Nature Neuroscience
Authors
Aarrestad, I. K., Cameron, L. P., Fenton, E. M., Casey, A. B., Rijsketic, D. R., Patel, S. D., Sambyal, R., Johnson, S. B., Viswanathan, J., Barragan, E. V., Lozano, S. A., Seban, N., Powell, N. A., Chytil, M., Meyer, R., Rose, D., Hempel, C., Olson, D. E., Olson, E., Hansen, H. D., Madsen, C. A., Knudsen, G. M., Redd, C., Wheeler, D. G., Guanzon, N., Muir, J., Quon, G., McCorvy, J. D., Rasmussen, K., Liston, C., Gray, J. A., Heifets, B. D., Nord, A. S., Kim, C. K., Ghandi, S. P., Hennesssey, J. J., Hu, H., Ly, C.
Open Accessindividual

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

This mice study investigated the antidepressant and neuroplastic effects of psychedelics, specifically lysergic acid diethylamide (LSD) and psilocin. The trial centres around their high-affinity binding to TrkB, a BDNF receptor implicated in antidepressant mechanisms. These substances bind to TrkB with affinities 1,000-fold higher than other antidepressants (SSRIs), and their effects on neurotrophic signalling, plasticity, and antidepressant-like behaviour in mice depend on this TrkB binding and promotion of endogenous BDNF signalling. Interestingly, these effects are independent of serotonin (5-HT) 2A receptor activation, suggesting that TrkB is a primary target for antidepressants.

Published
Journal
Nature Neuroscience
Authors
Moliner, R., Girych, M., Brunello, C. A., Biojone, C., Enkavi, G., Antenucci, L., Kot, E. F., Goncharuk, S. A., Kaurinkoski, K., Kuutti, M., Fred, S. M., Elsilä, L. V., Sakson, S., Cannarozzo, C., Diniz, C. R. A. F., Seiffert, N., Rubiolo, A., Haapaniemi, H., Meshi, E., Öhman, T., Rog, T., Kankuri, E., Vilar, M., Varjosalo, M., Korpi, E. R., Permi, P., Mineev, K. S., Saarma, M., Vattulainen, I., Casarotto, S., Castrén, E., Koveleva, V., Nagaeve, E.

Quick Facts

Papers Indexed
2
h-Index
496
Open Access
No
Publisher
Nature Portfolio
Country
United Kingdom
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