This review (2024) highlights preclinical research from the past 15 years showing that ketamine and psychedelics trigger dendritic spine growth in cortical pyramidal neurons, enhancing neural plasticity. It compares the longitudinal effects of psychoactive drugs, emphasizing rapid-onset and sustained structural plasticity as key features of rapid-acting antidepressants, and discusses gaps in understanding and prospects for other interventions like rTMS.
- Published
- Journal
- Nature Reviews Neuroscience
- Authors
- Dua, A. N., Kwan, A. C., Liao, C., Liston, C., Wojtasiewicz, C.