This animal study (n=72) investigated the molecular mechanisms underlying the antidepressant efficacy of ketamine (10, 25, and 50 mg/kg) and found that it may be partially attributed to the upregulation of excitatory amino acid transporters (EAATs) which enhance the reuptake of extracellular glutamate in the hippocampus of depressive-like rats.
- Published
- Journal
- Neuroscience Letters
- Authors
- Zhu, X., Ye, G., Wang, Z., Luo, J., Hao, X.