Repeated administration of psilocybin in healthy adults produced persistent positive psychological effects, and the acute phenomenology—particularly Oceanic Boundlessness, Visionary Restructuralization and peak experiences ending in a positive mood—predicted these long-term benefits independently of sex, prior psychedelic experience, setting or repeat dosing. Challenging or mixed acute experiences in the controlled laboratory did not produce lasting negative outcomes, supporting psilocybin’s psychological safety for repeated use in clinical trials.
- Published
- Journal
- Pharmacological Reports
- Authors
- Tylš, F., Páleníček, T., Klučková, T., Nikolič, M., Viktorin, V., Vejmola, Č., Viktorinová, M., Bravermanová, A., Androvičová, R., Andrashko, V., Korčák, J., Zach, P., Hájková, K., Kuchař, M., Balíková, M., Brunovský, M., Horáček, J.