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Academic Journal

Pharmacometrics and Systems Pharmacology

2 Papers Indexed in Blossom

Published Papers

Paywallindividual

MDMA pharmacokinetics: A population and physiologically based pharmacokinetics model-informed analysis

Using clinical, published and in vitro data, the authors developed and verified population and physiologically based pharmacokinetic models for MDMA which show that a high‑fat meal delays Tmax without changing overall exposure and that split dosing (2 h apart) lowers early AUC and delays Tmax compared with a single dose. The models further indicate MDMA is a potent CYP2D6 inhibitor but is unlikely to cause clinically meaningful drug–drug interactions via renal transporters, supporting model‑informed predictions of clinically relevant dosing regimens.

Published
Journal
Pharmacometrics and Systems Pharmacology
Authors
Miner, N. B.
Open Accessmeta

Optimized infusion rates for N,N-dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework

This study designed an infusion protocol for DMT using pharmacokinetic/pharmacodynamic modelling. Comparing a continuous variable model to two bounded integer models, optimal doses for desired psychedelic intensity were identified. However, achieving consistent target intensity was challenging across models, indicating individual dose adjustments might be needed. Differences between models were especially notable at the scale's boundaries.

Published
Journal
Pharmacometrics and Systems Pharmacology
Authors
Eckernäs, E., Koomen, J., Timmermann, |. C., Robin, |., Röshammar, D., Ashton, M.

Quick Facts

Papers Indexed
2
Publisher
Wiley
Website
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