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Academic Journal

Pharmacopsychiatry

11 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Factors Associated with Antidepressant Effects of Ketamine: A Reanalysis of Double-Blind Randomized Placebo-Controlled Trial of Intravenous Ketamine for Treatment-Resistant Depression

Reanalysis of a placebo‑controlled double‑blind RCT of intravenous ketamine in 31 adults with treatment‑resistant depression found that later age of depression onset predicted a greater antidepressant response three days after infusion, whereas age, sex, baseline severity and dissociative scores showed no association. The authors propose that impaired glutamatergic signalling and reduced neuroplasticity in earlier‑onset cases may explain the diminished ketamine response.

Published
Journal
Pharmacopsychiatry
Authors
Yonezawa, K., Uchida, H., Yatomi, T., Ohtani, Y., Nomoto-Takahashi, K., Nakajima, S., Mimura, M., Tani, H., Ac, A.
Open Accessmeta

Classic Psychedelic Drugs: Update on Biological Mechanisms

This review synthesises recent molecular-to-systems evidence that classic psychedelics act primarily at serotonergic receptor subtypes in cortico‑thalamic and cortico‑cortical feedback circuits, modulating excitatory–inhibitory balance and promoting neuroplasticity in regions that integrate sensation, cognition, emotion and the sense of self. Neuroimaging and behavioural data link these circuit-level changes to altered self‑experience, emotion regulation and social cognition, which may help explain psychedelics' therapeutic potential in psychiatric disorders.

Published
Journal
Pharmacopsychiatry
Authors
Vollenweider, F. X., Smallridge, J. W.
Paywallmeta

The Potential Role of Psychedelic Drugs in Mental Health Care of the Future

This review (2021) summarizes the challenges for creating a new treatment infrastructure for Psychedelic-assisted psychotherapy in the process of re-contextualizing psychopharmacological interventions within a paradigm that lays particular emphasis on preparation, integration, and the development of structured patient communities as crucial components of therapy.

Published
Journal
Pharmacopsychiatry
Authors
Gründer, G., Jungaberle, H., Gründer, G.
Open Accessindividual

Classic psychedelic coadministration with lithium, but not lamotrigine, is associated with seizures: an analysis of online psychedelic experience reports

Analysing reports from Erowid, Shroomery and Reddit, the authors found that 47% of 62 psychedelic experiences reported while taking lithium involved seizures (39% required medical attention), whereas none of 34 reports from people taking lamotrigine did. They provisionally conclude that classic psychedelics co‑administered with lithium — but not lamotrigine — may pose a substantial seizure risk and warrant further research.

Published
Journal
Pharmacopsychiatry
Authors
Nayak, S., Gukasyan, N., Barrett, F. S., Erowid, E., Erowid, F., Griffiths, R. R.
Paywallmeta

Classical Psychedelics as Therapeutics in Psychiatry - Current Clinical Evidence and Potential Therapeutic Mechanisms in Substance Use and Mood Disorders

This review summarises modern clinical evidence that classical psychedelics (primarily psilocybin, with LSD and ayahuasca) show promising but methodologically limited effects in substance use and unipolar mood disorders. It outlines shared pathophysiology, proposes hypotheses for putative therapeutic mechanisms based on preclinical and human data, and calls for larger, blinded randomised controlled trials to establish efficacy and mechanisms.

Published
Journal
Pharmacopsychiatry
Authors
Mertens, L. J., Preller, K. H.
Paywallmeta

Psychedelics and Psychotherapy

This book chapter (2020) in Pharmacopsychiatry provides an excellent review of our current understanding of psychedelics for psychotherapy.

Published
Journal
Pharmacopsychiatry
Authors
Nayak, S., Johnson, M. W.

Quick Facts

Papers Indexed
11
h-Index
86
Open Access
No
Publisher
Georg Thieme Verlag
Country
Germany
Website
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