Reanalysis of a placebo‑controlled double‑blind RCT of intravenous ketamine in 31 adults with treatment‑resistant depression found that later age of depression onset predicted a greater antidepressant response three days after infusion, whereas age, sex, baseline severity and dissociative scores showed no association. The authors propose that impaired glutamatergic signalling and reduced neuroplasticity in earlier‑onset cases may explain the diminished ketamine response.
- Published
- Journal
- Pharmacopsychiatry
- Authors
- Yonezawa, K., Uchida, H., Yatomi, T., Ohtani, Y., Nomoto-Takahashi, K., Nakajima, S., Mimura, M., Tani, H., Ac, A.