Using population PK/PD modelling of intravenous DMT in 13 healthy volunteers, the study quantified concentration–response relationships for EEG, showing complete suppression of alpha power (EC50,e ≈ 71 nM), partial suppression of beta power (EC50,e ≈ 137 nM) and an increase in Lempel–Ziv complexity (EC50,e ≈ 54 nM). Beta power and complexity exhibited high between‑subject variability (CV ≈ 75–77%) while alpha was more consistent (CV 29%), indicating alpha power may be the most robust biomarker for dose selection.
- Published
- Journal
- Philosophy and the Mind Sciences
- Authors
- Eckernäs, E., Timmermann, C., Carhart-Harris, R., Röshammar, D., Ashton, M.