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Philosophy and the Mind Sciences

2 Papers Indexed in Blossom

Published Papers

Open Accessindividual

N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analysis

Using population PK/PD modelling of intravenous DMT in 13 healthy volunteers, the study quantified concentration–response relationships for EEG, showing complete suppression of alpha power (EC50,e ≈ 71 nM), partial suppression of beta power (EC50,e ≈ 137 nM) and an increase in Lempel–Ziv complexity (EC50,e ≈ 54 nM). Beta power and complexity exhibited high between‑subject variability (CV ≈ 75–77%) while alpha was more consistent (CV 29%), indicating alpha power may be the most robust biomarker for dose selection.

Published
Journal
Philosophy and the Mind Sciences
Authors
Eckernäs, E., Timmermann, C., Carhart-Harris, R., Röshammar, D., Ashton, M.
Open Accessmeta

Dissolving the self: Active inference, psychedelics, and ego-dissolution

The paper presents an active inference account of psychedelic-induced ego-dissolution, arguing that psychedelics lower precision on high-level priors (raising the Bayesian learning rate) which collapses the temporal thickness of the deep generative model and thereby dissolves the self-model. This framework links ego-dissolution to mechanisms underlying ordinary self-consciousness and its disturbances in conditions such as psychosis, autism, depression and dissociative disorders.

Published
Journal
Philosophy and the Mind Sciences
Authors
Deane, G.

Quick Facts

Papers Indexed
2
h-Index
15
Open Access
Yes
Publisher
MIND Group
Country
Germany
Website
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