This cell-based study investigates the role of serotonin receptors in the claustrum's response to psychedelic drugs. It finds that the claustrum is rich in 5-HT2C receptors on glutamatergic neurons and that serotonin and the psychedelic DOI have opposite effects on synaptic signalling, both mediated by 5-HT2C receptors rather than 5-HT2A receptors as previously thought.
- Published
- Journal
- Progress in Neurobiology
- Authors
- Anderson, T. L., Keady, J. V., Songrady, J., Tavakoli, N. S., Asadipooya, A., Neeley, R. E., Turner, J. R., Ortinski, P. I.