This community-based study (n=295) examined the impact of intravenous ketamine treatment on suicidality. Using growth mixture modelling, three trajectory groups were identified: one with moderate baseline scores showing gradual improvement (n=170, 57.6%), another with severe baseline scores showing no improvement (n=63, 21%), and a third with rapid improvement (n=62, 21%). Among clinical and demographic variables, only higher scores on active thoughts of death and/or plan predicted a lack of benefit from treatment for those with severe baseline CHRT-SR scores. The findings support ketamine's potential effectiveness in addressing suicidality in a proportion of patients.
- Published
- Journal
- Psychiatry Research
- Authors
- O'Brien, B., Lee, J., Kim, S., Nandra, G. S., Pannu, P., Tamman, A. J. F., Amarneh, D., Swann, A. C., Murphy, N., Averill, L. A., Jha, M. K., Mathew, S. J.