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Academic Journal

Psychiatry Research

24 Papers Indexed in Blossom

Published Papers

Open Accessmeta

Psychedelics as a potential treatment for borderline personality disorder: A narrative review

This narrative review (s=22) examined studies of ketamine, esketamine and psilocybin in people with borderline personality disorder and found early evidence that they may help core symptoms and social and work functioning. It also noted that patients with BPD are often excluded from research because of safety concerns, especially around suicide and substance misuse.

Published
Journal
Psychiatry Research
Authors
Artna, E., Sandhu, G., Chisamore, N., Lipsitz, O., Kaczmarek, E. S., Johnson, D. E., Rosenblat, J. D., Sediqzadah, S.
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Trip sitting or just sitting? Session facilitators substantially influence psychedelic experiences in clinical trials but not in healthy ones

This pooled analysis (s=9) examined how much session facilitators shape participants' acute subjective effects across psilocybin studies involving 298 participants and 60 facilitators, finding that facilitator influence was negligible in healthy volunteers (0.8% of variance) but clinically meaningful in patient samples (13.6%), comparable to or exceeding typical therapist effects seen in conventional psychotherapy.

Published
Journal
Psychiatry Research
Authors
Goldy, S. P., Sepeda, N. D., Hilbert, S. N., Bari, B. A., Garcia-Romeu, A., Gukasyan, N., Barrett, F. S., Yaden, D. B., Nayak, S. M.
Open Accessindividual

IV low dose ketamine infusions for treatment resistant depression: Results from a five-year study at a free public clinic in an academic hospital

This longitudinal study (n=71) examines five years of real-world clinical data on the use of IV low-dose ketamine alongside standard care for outpatients with depression (MDD & TRD). Results indicate a significant reduction in depressive symptoms and suicide ideation by treatment endpoint, with 55% of patients responding to treatment. Side effects were transient and mild for 78% of patients, with a dropout rate of 11%. Multivariate analysis suggests that demographic variables did not impact treatment efficacy or tolerability.

Published
Journal
Psychiatry Research
Authors
Gutierrez, G., Kang, M. J. Y., Vasquez, G.
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Anti-suicidal effects of IV ketamine in a real-world setting

This community-based study (n=295) examined the impact of intravenous ketamine treatment on suicidality. Using growth mixture modelling, three trajectory groups were identified: one with moderate baseline scores showing gradual improvement (n=170, 57.6%), another with severe baseline scores showing no improvement (n=63, 21%), and a third with rapid improvement (n=62, 21%). Among clinical and demographic variables, only higher scores on active thoughts of death and/or plan predicted a lack of benefit from treatment for those with severe baseline CHRT-SR scores. The findings support ketamine's potential effectiveness in addressing suicidality in a proportion of patients.

Published
Journal
Psychiatry Research
Authors
O'Brien, B., Lee, J., Kim, S., Nandra, G. S., Pannu, P., Tamman, A. J. F., Amarneh, D., Swann, A. C., Murphy, N., Averill, L. A., Jha, M. K., Mathew, S. J.
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Psilocybin-assisted therapy for depression: A systematic review and meta-analysis

This systematic review analyzed the effects of psilocybin on depressive symptoms in patients diagnosed with life-threatening illnesses or major depressive disorder. The review included 13 studies with a total of 686 participants, and the meta-analysis of 9 studies (596 participants) found a significant and large effect in favor of psilocybin (SMD = -0.78; p<0.001) for reducing depressive symptoms. The review suggests preliminary evidence supporting the antidepressant efficacy of psilocybin-assisted psychotherapy but calls for further studies to assess safety, efficacy, and treatment optimization.

Published
Journal
Psychiatry Research
Authors
Haikazian, S., Chen-Li, D., Johnson, D., Fancy, F., Levinta, A., Husain, M. I., Mansur, R. B., McIntyre, R. S., Rosenblat, J. D.
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Attention deficit hyperactivity disorder symptoms and lifetime use of psychoactive substances among French university students: A cross-sectional study

This observational survey study of university students (n=13,837) explored the association between ADHD symptoms and lifetime psychoactive substance use. It finds a significant correlation between high levels of ADHD symptoms and the use of various substances, including ketamine and psilocybin mushrooms.

Published
Journal
Psychiatry Research
Authors
Jean, F. A. M., Schwartz, A. N., Galesne, C., Azouz, Z., Navarro, M. C., Montagni, I., Macalli, M., Côté, S. M., Tzourio, C., Galéra, C.

Quick Facts

Papers Indexed
24
h-Index
187
Open Access
No
Publisher
Elsevier
Country
Ireland
Website
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