This rat study found that the ibogaine-derived compound oxa-noribogaine reduced alcohol drinking and relapse-like drinking by strengthening learning from negative drinking outcomes and changing glutamatergic activity in the prefrontal cortex. It also appeared to match or exceed ibogaine’s effects without detectable motor or cardiac problems.
- Published
- Journal
- Research Square
- Authors
- Meinhardt, M., Skorodumov, I., Walter, F., Akan, M., Buchborn, T., PRIEULT, Y. L., Urban, M., Spanagel, R., von Ammon, L., Hopf, C., Kalinichenko, L., Mueller, C., Winter, C., Hadar, R., Gül, A. Z., Massuda, B., Hildebrandt, M., Domi, E., Keshishian, A., Ciccocioppo, R., Sames, D., Havel, V., Woods, L., Beeson, A.