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13 Papers Indexed in Blossom

Published Papers

Open Accessindividual

DMT, Madness, and Healing: Psychosis Model, Therapy Model, and Their Relations to Mystical Experiences and Positive Emotionality

This randomised, placebo-controlled, double-blind crossover study (n=25) found that DMT (60 mg) increased psychotic-like experiences and suggestibility in healthy volunteers, alongside strong mystical and other psychedelic effects. The links between these effects appeared to be driven more by positive emotionality than by mystical experience alone.

Published
Journal
Research Square
Authors
Wießner, I., Falchi-Carvalho, M., Laborde, S., Barros, H., Bolcont, R., Medina, M., Mograbi, D., Coelho, N. G., Palhano-Fontes, F., Araujo, D.
Open Accessindividual

When Therapy Falls Short: A Qualitative Study of Psychotherapy After Challenging Psychedelic Experiences

This qualitative study (n=35) explored psychotherapy experiences after challenging naturalistic psychedelic experiences and found that many people felt misunderstood, judged, or poorly supported by therapists. Participants often hid their distress, turned to self-directed support, and described a mismatch between their recovery pace and clinicians’ expectations.

Published
Journal
Research Square
Authors
Simon, G., Tadmor, N., Evans, J., Luke, D., Luoma, J.
Open Accessindividual

Extended difficulties after psychedelic experiences: Prevalence and associations in a global, multilingual sample

This survey study (n=6,476) examined long-lasting difficulties after psychedelic use in a global multilingual sample and found that nearly half reported problems lasting at least 24 hours, with existential struggle, depression and derealisation most common. About 28% reported disruptive difficulties lasting at least a month, which were linked to younger age, lower income, less family support, lower emotional stability and higher pre-existing anxiety or depression.

Published
Journal
Research Square
Authors
Oliver, C. R., Luke, D., Evans, J., Jacob, S. A., Johnson, M., Lake, S., Kruger, D., Kevin, F. B., Lucas, P.
Open Accessindividual

Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC

This rat study found that the ibogaine-derived compound oxa-noribogaine reduced alcohol drinking and relapse-like drinking by strengthening learning from negative drinking outcomes and changing glutamatergic activity in the prefrontal cortex. It also appeared to match or exceed ibogaine’s effects without detectable motor or cardiac problems.

Published
Journal
Research Square
Authors
Meinhardt, M., Skorodumov, I., Walter, F., Akan, M., Buchborn, T., PRIEULT, Y. L., Urban, M., Spanagel, R., von Ammon, L., Hopf, C., Kalinichenko, L., Mueller, C., Winter, C., Hadar, R., Gül, A. Z., Massuda, B., Hildebrandt, M., Domi, E., Keshishian, A., Ciccocioppo, R., Sames, D., Havel, V., Woods, L., Beeson, A.
Open Accessindividual

Age moderates the relationship between psychedelics use and mental health in naturalistic settings

This cross-sectional survey (n=1,088) found that age significantly moderates the relationship between lifetime psychedelic use and mental health, with classic psychedelics such as psilocybin being associated with lower depression and anxiety in younger adults, but these benefits diminish with age and even reverse for anxiety in older participants.

Published
Journal
Research Square
Authors
Gregorio, G. D., Basset, S., Manmohan, H., Nixon, W. C., Pogaku, A., Zhou, J., Sanderson, D. J., Lengieza, M. L., Bocchio, M.
Open Accessindividual

Psychedelics are associated with changes in spiritual beliefs and orientations in US veterans

In a retrospective survey of 151 primarily US veterans who attended psychedelic-based treatment, participants reported a significant rise in active belief in God or a higher power and a decline in explicit non-belief after their most memorable psychedelic experience, with no significant change in formal religious or spiritual affiliation but qualitative shifts in their relationship to spirituality. These results suggest psychedelics can catalyse increased spiritual connection and reorientation, especially among prior doubters or nonbelievers.

Published
Journal
Research Square
Authors
Brown, R. E., Shinozuka, K., Kaloiani, I., Kozyr, L., Orion, D., Faerman, A., Adamson, M. M.

Quick Facts

Papers Indexed
13
Publisher
Springer Nature
Website
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