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11 Papers Indexed in Blossom

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Extended difficulties after psychedelic experiences: Prevalence and associations in a global, multilingual sample

This survey study (n=6,476) examined long-lasting difficulties after psychedelic use in a global multilingual sample and found that nearly half reported problems lasting at least 24 hours, with existential struggle, depression and derealisation most common. About 28% reported disruptive difficulties lasting at least a month, which were linked to younger age, lower income, less family support, lower emotional stability and higher pre-existing anxiety or depression.

Published
Journal
Research Square
Authors
Oliver, C. R., Luke, D., Evans, J., Jacob, S. A., Johnson, M., Lake, S., Kruger, D., Kevin, F. B., Lucas, P.
Open Accessindividual

Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC

This rat study found that the ibogaine-derived compound oxa-noribogaine reduced alcohol drinking and relapse-like drinking by strengthening learning from negative drinking outcomes and changing glutamatergic activity in the prefrontal cortex. It also appeared to match or exceed ibogaine’s effects without detectable motor or cardiac problems.

Published
Journal
Research Square
Authors
Meinhardt, M., Skorodumov, I., Walter, F., Akan, M., Buchborn, T., PRIEULT, Y. L., Urban, M., Spanagel, R., von Ammon, L., Hopf, C., Kalinichenko, L., Mueller, C., Winter, C., Hadar, R., Gül, A. Z., Massuda, B., Hildebrandt, M., Domi, E., Keshishian, A., Ciccocioppo, R., Sames, D., Havel, V., Woods, L., Beeson, A.
Open Accessindividual

Age moderates the relationship between psychedelics use and mental health in naturalistic settings

This cross-sectional survey (n=1,088) found that age significantly moderates the relationship between lifetime psychedelic use and mental health, with classic psychedelics such as psilocybin being associated with lower depression and anxiety in younger adults, but these benefits diminish with age and even reverse for anxiety in older participants.

Published
Journal
Research Square
Authors
Gregorio, G. D., Basset, S., Manmohan, H., Nixon, W. C., Pogaku, A., Zhou, J., Sanderson, D. J., Lengieza, M. L., Bocchio, M.
Open Accessindividual

Psychedelics are associated with changes in spiritual beliefs and orientations in US veterans

In a retrospective survey of 151 primarily US veterans who attended psychedelic-based treatment, participants reported a significant rise in active belief in God or a higher power and a decline in explicit non-belief after their most memorable psychedelic experience, with no significant change in formal religious or spiritual affiliation but qualitative shifts in their relationship to spirituality. These results suggest psychedelics can catalyse increased spiritual connection and reorientation, especially among prior doubters or nonbelievers.

Published
Journal
Research Square
Authors
Brown, R. E., Shinozuka, K., Kaloiani, I., Kozyr, L., Orion, D., Faerman, A., Adamson, M. M.
Open Accessindividual

Psilocybin’s effect on human brain synaptic plasticity

A single psilocybin dose increased frontal and hippocampal synaptic density in healthy participants one week after dosing, measured with [11C]UCB-J PET targeting synaptic vesicle glycoprotein 2A (SV2A). Participants dosed in a therapeutic-like room showed stronger mystical-type experiences, longer-lasting psychological benefits and greater synaptic increases than those dosed inside an MRI scanner, indicating that psilocybin’s neuroplastic effects are modulated by environmental context.

Published
Journal
Research Square
Authors
Johansen, A., Plavén-Sigray, P., Madsen, M. K., Søndergaard, A., Messel, C., Geisler, M., Nasser, A., McCulloch, D. E-W., Beliveau, V., Vassilieva, A., Lund, A., Lehel, S., Ozenne, B., Stenbæk, D. S., Fisher, P. M., Svarer, C.
Open Accessindividual

The Effect of Psychedelics on Individuals with a Personality Disorder: Results from two Prospective Cohort Studies

In two prospective cohort studies of people with a diagnosed personality disorder, psychedelic use was associated with moderate reductions in anxiety and depressive symptoms and increases in cognitive reappraisal, with transient improvements in cognitive flexibility. Clinically significant elevations in suicidal behaviour were rare, though several participants experienced worsened anxiety or depression; findings are limited by small samples, self‑report data and lack of differentiation between PD subtypes.

Published
Journal
Research Square
Authors
Gordon, A. R., Carrithers, B. M., Pagni, B. A., Kettner, H., Nayak, S., Weiss, B. J., Carhart-Harris, R. L., Roberts, D. E., Zeifman, R. J.

Quick Facts

Papers Indexed
11
Publisher
Springer Nature
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