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4 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Navigating Groundlessness: An interview study on dealing with ontological shock and existential distress following psychedelic experiences

This qualitative study (n=26) explored existential distress following psychedelic experiences, finding persistent preoccupation with sense-making and confusion about existence and purpose. Participants reported cognitive, emotional, social, bodily, and functional impacts. They managed distress through embodiment practices and social/cognitive normalization.

Published
Journal
SSRN
Authors
Argyri, E. K., Evans, J., Luke, D., Michael, P., Michelle, K., Rohani- Shukla, C., Suseelan, S., Prideaux, E., Mcalpine, R., Murphy-Beiner, A., Robinson, O. C.
Paywallindividual

How Low-Doses Of Psychedelics Compliment High Dose Experiences: Observational Evidence In Naturalistic Settings

This preprint (n=41) explores how people use low doses of psychedelics to complement high-dose therapeutic and spiritual experiences by conducting a secondary analysis of interviews from a private-sector wellness company that provides psychedelics educational materials and coaching. High-dose psychedelics are most often meaningful for belief re-appraisal and acute mental illness, while lose-dose experiences benefit behavioural change, relationship development, and managing episodic stress. Low dosing appears to help users “integrate” the existential and therapeutic insights from high doses by improving in-the-moment mindfulness of everyday challenges.

Published
Journal
SSRN
Authors
Ferenstein, G.
Paywallindividual

5-HT2CR Is as Important as 5-HT2AR in Inducing Hallucinogenic Effects in Serotonergic Compounds

This rodent study (2022) shows that the activation of serotonin receptors (5-HT) by mescaline derivatives via 5-HT2CR, alone or in concert with 5-HT2AR, produces comparable hallucinogenic effects to activation via divergent 5-HT2CR- and/or 5-HT2AR signalling pathways. Given that many believe 5-HT2AR activation is the route through which psychedelics exert their effects, these findings show that 5-HT2CR is as important as 5-HT2AR in inducing these effects.

Published
Journal
SSRN
Authors
James Perez Custodio, R., Ortiz, D. M., Lee, H. J., Sayson, L. V., Buctot, D., Kim, M., Lee, Y. S., Kim, K. M., Cheong, J. H., Kim, H. J.
Open Accessindividual

Patents on Psychedelics: The Next Legal Battlefront of Drug Development

This essay (2021) is one of the first publications to emerge from the POPLAR initiative at Harvard Law School. The essay explores issues regarding the patenting of psychedelics given their controversial history and offers suggestions on how to reduce the risk of biopiracy and the issuance of meritless psychedelic patents.

Published
Journal
SSRN
Authors
Marks, M., Cohen, I. G.

Quick Facts

Papers Indexed
4
Publisher
Elsevier
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