This review (2012) postulates that DMT may play a role in cell protection, regeneration, and immunity by activating a cell-endogenous sigma-1 receptor pathway which regulates oxidative stress-induced changes at the endoplasmic reticulum-mitochondria interface. Supportive experimental data are still necessary for advancing the outlined concepts, such as the endogenous role of DMT or the immunoprotective benefits of exogenous DMT ingested in larger quantities.
- Published
- Journal
- Translational Neurosciences
- Authors
- Frecska, E., Szabo, A., Winkelman, M. J., Luna, L. E., Mckenna, D. J.