EQ-5D-5L

The EuroQol 5-Dimension 5-Level (EQ-5D-5L) is a brief standardized measure of health-related quality of life developed by the EuroQol Group. It comprises five dimensions — mobility, self-care, usual activities, pain/discomfort, and anxiety/depression — each with five severity levels (no problems to extreme problems), plus a visual analog scale (EQ-VAS, 0–100) for self-rated health. The five dimensions generate a health state profile that can be converted to a single index value (typically -0.5 to 1.0) using country-specific value sets, enabling health economic analyses such as quality-adjusted life years (QALYs). The EQ-5D-5L is increasingly important in psychedelic clinical trials because health technology assessment bodies (NICE, IQWiG, ZIN) require utility-based QoL data for reimbursement decisions. Including the EQ-5D-5L provides the health economic evidence needed to support payer coverage of psychedelic-assisted therapies.