Outcome MeasurePersonality / Psychological

NEO-FFI

NEO Five-Factor Inventory

3 Papers in Blossom

Outcome Data Across Studies

Reported results for NEO-FFI across 1 study with quantitative data.

Outcome data across 4 study arm–timepoint observations
SD
LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up
2024Exploratory
LSD(experimental)03935.15.8—
LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up
2024Exploratory
LSD(experimental)7143323.07.3—
LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up
2024Exploratory
Placebo(inactive)03934.06.5—
LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up
2024Exploratory
Placebo(inactive)7143329.07.2—

Papers Using NEO-FFI

Open Accessindividual

Moderating factors in psilocybin-assisted treatment affecting mood and personality: A naturalistic, open-label investigation

In a naturalistic, open‑label study a single high dose of psilocybin with psychotherapy produced sustained reductions in depression, anxiety, PTSD symptoms and neuroticism, and increases in openness and conscientiousness at three months. The size of these benefits was moderated by participants’ subjective dosing experiences (mystical‑type experiences, emotional breakthrough and post‑treatment growth) and demographic factors, highlighting variables that may help optimise psilocybin‑assisted treatment.

Published
Journal
Psychopharmacology
Authors
Irrmischer, M., Puxty, D. J., Deijen, J. B., Engelbregt, H., Yildirim, B. O.
Open Accessindividual

LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up

In a planned 12‑month open‑label follow‑up of a double‑blind, placebo‑controlled crossover trial, LSD‑assisted therapy produced sustained, clinically significant reductions in anxiety and depression with large effect sizes lasting up to nearly two years after treatment. Participants also showed decreased neuroticism, increased extraversion and reported positive long‑term effects attributed to the psychedelic experience.

Published
Journal
BJPsych Open
Authors
Holze, F., Gasser, P., Müller, F., Strebel, M., Liechti, M. E.
Open Accessindividual

Effects of psilocybin therapy on personality structure

In 20 patients with treatment‑resistant depression, two psilocybin sessions with psychological support produced significant 3‑month decreases in Neuroticism and increases in Extraversion and Openness (Conscientiousness trended upward; Agreeableness was unchanged). The degree of insightfulness during the session predicted these changes, suggesting pronounced increases in Extraversion and Openness may be characteristic of psychedelic therapy and warrant confirmation in controlled studies.

Published
Journal
Acta Psychiatrica Scandinavica
Authors
Erritzoe, D., Roseman, L., Nour, M. R., MacLean, K. A., Kaelen, M., Nutt, D. J., Carhart-Harris, R. L.

Quick Facts

Full Name
NEO Five-Factor Inventory
Domain
Personality / Psychological
Papers Indexed
3
Score Range
0–48
Interpretation
Higher = better
Unit
points per domain
Reference
Visit
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