PRISE

The Patient-Rated Inventory of Side Effects (PRISE) is a self-report questionnaire used to systematically assess treatment-emergent side effects across multiple body systems. It covers nine symptom domains: gastrointestinal, cardiovascular, dermatological, neurological, eyes/ears, genital/urinary, sleep, sexual functioning, and other. For each domain, patients indicate whether they experienced symptoms and rate whether the symptoms were tolerable or distressing. Developed at Massachusetts General Hospital, the PRISE is commonly used in psychopharmacology trials and has been adopted in psychedelic research to capture the safety and tolerability profile of psychedelic compounds. Unlike clinician-rated adverse event logs, the PRISE captures the patient’s subjective experience of side effects, making it a valuable complement to standard safety monitoring.