Equity and Ethics

A Transformative Trip? Experiences of Psychedelic Use

Analysing interviews with 26 retreat participants, the study finds that psychedelic experiences can constitute transformative experiences: 20 participants reported insights seemingly inaccessible without psychedelics and 25 of 26 reported changes in identity, values, desires or behaviour (behavioural change was most common). The authors argue this raises neuroethical concerns about consent and moral psychopharmacology and call for person-centred research and ethical inquiry.

Authors

  • Neitzke-Spruill, L.
  • Beit, C.
  • Robinson, J.

Published

Neuroethics
individual Study

Abstract

Psychedelic experiences are often compared to “transformative experiences” due to their potential to change how people think and behave. This study empirically examines whether psychedelic experiences constitute transformative experiences. Given psychedelics’ prospective applications as treatments for mental health disorders, this study also explores neuroethical issues raised by the possibility of biomedically directed transformation—namely, consent and moral psychopharmacology. To achieve these aims, we used both inductive and deductive coding techniques to analyze transcripts from interviews with 26 participants in psychedelic retreats. Results indicate that psychedelic experiences can constitute transformative experiences. Twenty participants reported experiences or insights that were seemingly inaccessible or impossible to attain if not for the psychoactive effects of psychedelics. All participants besides one reported some change in identity, values, beliefs, desires, and behavior—changes in behavior being the most common. Participants also reported feeling capable deciding to use psychedelics in part due to information seeking prior to their retreats. Finally, several participants reported an enhanced capacity for enacting changes in their lives. Our results underscore both the importance of subjective embodiment to transformation and the role of transformative agency in shaping outcomes of the psychedelic experience. We examine our results relative to neuroethical issues and advocate for centering the person in psychedelic research and neuroethical inquiry about psychedelics to avoid pitfalls associated with psychedelics’ potential as moral psychopharmacological agents.

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Research Summary of 'A Transformative Trip? Experiences of Psychedelic Use'

Introduction

Psychedelics have received renewed scientific, regulatory, and public attention because of promising therapeutic applications and a narrative that they can produce rapid, profound changes in how people think and act. Neitzke-Spruill and colleagues frame this paper around L.A. Paul’s philosophical account of "transformative experiences," which distinguishes epistemic transformation (gaining knowledge that can only be acquired through having an experience) from personal transformation (substantial change to one’s point of view, core preferences, or sense of self). The authors note that, despite theoretical overlap between psychedelic experiences and Paul’s notion of transformation, no prior study has empirically assessed whether people regard their psychedelic experiences as epistemically and personally transformative according to Paul's criteria, nor systematically examined how retreat participants make decisions to pursue such experiences. This study sets out to fill that gap by interviewing individuals who attended psychedelic retreats to determine whether their self-reported experiences meet Paul's criteria for transformative experience and to explore related neuroethical questions. In particular, the investigators examine participants’ reports about (1) novel insights or knowledge attributable to psychedelics, (2) changes in identity, values, beliefs, desires, or behaviour, (3) how participants described their experiences using everyday language, and (4) whether participants felt able to make informed decisions to attend retreats. The analysis also considers implications for consent and for concerns about psychedelic-facilitated moral psychopharmacology.

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Study Details

  • Study Type
    individual
  • Journal
  • Topic
  • APA Citation

    Neitzke-Spruill, L., Beit, C., Robinson, J., Blevins, K., Reynolds, J., Evans, N. G., & McGuire, A. L. (2024). A Transformative Trip? Experiences of Psychedelic Use. Neuroethics, 17(2). https://doi.org/10.1007/s12152-024-09567-0

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