Depressive DisordersAnxiety DisordersSubstance Use Disorders (SUD)Palliative & End-of-Life DistressSet & SettingPersonality & Trait FactorsAyahuascaLSDPsilocybin

Experience of Music Used With Psychedelic Therapy: A Rapid Review and Implications

This rapid review of 10 studies (n=180) found music to be a central component of psychedelic therapy, profoundly shaping emotional, imagery and embodied experiences—simultaneously anchoring and propelling participants—and that participant openness and participant-centred music selection associate with better immediate and longer-term outcomes. The authors recommend richer reporting on musical stimuli and greater involvement of music therapists to develop flexible, optimised music protocols for psychedelic-assisted treatment.

Authors

  • Martin Williams

Published

Journal of Music Therapy
meta Study

Abstract

Bonny Method of Guided Imagery and Music emerged following discontinuation of psychedelic therapy research in the early 1970s, but psychedelic therapy research has since revived. Music remains a vital component. This study examined participants’ experiences of music in psychedelic therapy research. A rapid review of qualitative and quantitative journal articles in four major databases was conducted in February to April, 2019, using the terms hallucinogens, psychedelic, “lysergic acid diethylamide,” psilocybin, ayahuasca, music, and/or “music therapy.” Of 406 articles retrieved, 10 were included (n = 180; 18–69 years old). Participants had varied backgrounds. Music was widely considered integral for meaningful emotional and imagery experiences and self-exploration during psychedelic therapy. Music transformed through its elicitation of anthropomorphic, transportive, synesthetic, and material sensations. Music could convey love, carry listeners to other realms, be something to “hold,” inspire, and elicit a deep sense of embodied transformation. Therapeutic influence was especially evident in music’s dichotomous elicitations: Music could simultaneously anchor and propel. Participant openness to music and provision of participant-centered music were associated with optimal immediate and longer-term outcomes. Many studies reported scarce details about the music used and incidental findings of music experienced. Further understanding of participants’ idiosyncratic and shared responses to music during drug therapy phases will inform optimal development of flexible music protocols which enhance psychedelic therapy. Music therapists could be involved in the psychedelic therapy research renaissance through assisting with research to optimize music-based protocols used. If psychedelics become approved medicines, music therapists may be involved in offering psychedelic therapy as part of therapeutic teams.

Available with Blossom Pro

Research Summary of 'Experience of Music Used With Psychedelic Therapy: A Rapid Review and Implications'

Introduction

Psychedelic drugs such as LSD and psilocybin act primarily on serotonin 5HT2A/2C receptors and produce alterations in emotion, cognition, and perception. Research into their therapeutic use began in the mid-20th century and indicated potential benefits for conditions including anxiety, depression, addiction, and existential distress among patients with life‑threatening illness. Political and regulatory backlash from the 1970s greatly reduced clinical research until a resurgence from the 1990s onwards, with contemporary studies emphasising psilocybin because of its low toxicity and relatively short duration of action (typical sessions about 8 hours). Music has been a persistent component in psychedelic-assisted sessions since early work, with historical and contemporary researchers proposing that carefully chosen music can support emotional release, peak or mystical experiences, and continuity during altered states. O'Callaghan and colleagues carried out a rapid review to examine participants’ first‑hand experiences of music used in psychedelic therapy employing psilocybin, LSD, or ayahuasca. The stated aim was to synthesise participant-reported music experiences to inform playlist design and broader guidance for music provision in forthcoming psilocybin-assisted psychotherapy research, particularly in work addressing depression and anxiety associated with life‑threatening illness. The review therefore focuses specifically on participant self‑reports about music, rather than therapist perspectives or ethnographic descriptions of nonclinical use.

Expert Research Summaries

Go Pro to access AI-powered section-by-section summaries, editorial takes, and the full research toolkit.

Full Text PDF

Full Paper PDF

Pro members can view the original manuscript directly in the browser.

Study Details

References (28)

Papers cited by this study that are also in Blossom

Psychedelics and music: neuroscience and therapeutic implications

Barrett, F. S., Preller, K. H., Kaelen, M. · International Review of Psychiatry (2018)

Psychedelics: Where we are now, why we got here, what we must do

Belouin, S. J., Henningfield, J. E. · Neuropharmacology (2018)

Patient Experiences of Psilocybin-Assisted Psychotherapy: An Interpretative Phenomenological Analysis

Belser, A. B., Agin-Liebes, G. I., Swift, T. C. et al. · Journal of Humanistic Psychology (2017)

Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

Carhart-Harris, R. L., Bolstridge, M., Rucker, J. et al. · Lancet Psychiatry (2016)

1174 cited
Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction

Garcia-Romeu, A., Griffiths, R. R., Johnson, M. W. · Current Drug Abuse Reviews (2015)

Show all 28 references
Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

Griffiths, R. R., Johnson, M. W., Richards, W. A. et al. · Psychopharmacology (2011)

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance

Griffiths, R. R., Richards, W. A., Mccann, U. et al. · Journal of Psychopharmacology (2006)

Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer

Grob, C. S., Danforth, A. L., Chopra, G. S. et al. · JAMA Psychiatry (2011)

Long-term follow-up of psilocybin-facilitated smoking cessation

Johnson, M. W., Garcia-Romeu, A., Griffiths, R. R. · The American Journal of Drug and Alcohol Abuse (2016)

562 cited
An online survey of tobacco smoking cessation associated with naturalistic psychedelic use

Johnson, M. W., Garcia-Romeu, A., Johnson, P. S. et al. · Journal of Psychopharmacology (2017)

117 cited
Human hallucinogen research: guidelines for safety

Johnson, M. W., Richards, W. A., Griffiths, R. R. · Journal of Psychopharmacology (2008)

LSD enhances the emotional response to music

Kaelen, M., Barrett, F. S., Roseman, L. et al. · Psychopharmacology (2015)

The hidden therapist: evidence for a central role of music in psychedelic therapy

Kaelen, M., Giribaldi, B., Raine, J. et al. · Psychopharmacology (2018)

213 cited
Therapeutic effects of ritual ayahuasca use in the treatment of substance dependence: qualitative results

Loizaga-Velder, A., Verres, R. · Journal of Psychoactive Drugs (2014)

Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder

Moreno, F. A., Wiegand, C. B., Taitano, E. K. et al. · Journal of Clinical Psychiatry (2006)

Psychedelics

Nichols, D. E. · Pharmacological Reviews (2016)

Psychedelic therapy for smoking cessation: Qualitative analysis of participant accounts

Noorani, T., Garcia-Romeu, A., Swift, T. C. et al. · Journal of Psychopharmacology (2018)

Cancer at the dinner table: experiences of psilocybin-assisted psychotherapy for the treatment of cancer-related distress

Swift, T. C., Belser, A. B., Agin-Liebes, G. et al. · Journal of Humanistic Psychology (2017)

130 cited
Ayahuasca’s entwined efficacy: an ethnographic study of ritual healing from ‘addiction’

Talin, P., Sanabria, E. · International Journal of Drug Policy (2017)

93 cited
50 cited
Patients’ accounts of increased “Connectedness” and “Acceptance” after psilocybin for treatment-resistant depression

Watts, R., Day, C. M., Krzanowski, J. et al. · Journal of Humanistic Psychology (2017)

Cited By (7)

Papers in Blossom that reference this study

Synergies in psychedelic-assisted therapy: a qualitative interview study of psychotherapeutic processes

Stellmacher, J., Schmidt, C., Aicher, H. D. et al. · Frontiers in Psychiatry (2026)

Set and setting in psilocybin-assisted therapy: A qualitative study of patients with cancer and depression

Beaussant, Y., Tarbi, E., Nigam, K. B. et al. · General Hospital Psychiatry (2025)

Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder

Weiss, B., Leor Roseman, •., Giribaldi, B. et al. · International Journal of Mental Health and Addiction (2024)

Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential

Allen, J., Dames, S., Foldi, C. J. et al. · Molecular Psychiatry (2024)

4 cited
Effect of LSD and music on the time-varying brain dynamics

Adamska, I., Finc, K. · Psychopharmacology (2023)

7 cited

Your Personal Research Library

Go Pro to save papers, add notes, rate studies, and organize your research into custom shelves.

Experience of Music Used With Psychedelic... — Research Summary & Context | Blossom