Relational and Growth Outcomes Following Couples Therapy With MDMA for PTSD
In a pilot trial of Cognitive Behavioural Conjoint Therapy for PTSD combined with two MDMA‑assisted psychotherapy sessions in six romantic dyads, both partners reported sustained improvements in post‑traumatic growth, relational support and social intimacy, reduced behavioural accommodation and conflict, and patients reported improved psychosocial functioning and empathic concern that were maintained through 6‑month follow‑up. These findings suggest dyadic CBCT with MDMA can produce durable relational and growth benefits alongside symptom-focused PTSD treatment.
Authors
- Michael Mithoefer
- Mark Wagner
- Anne Wagner
Published
Abstract
Healing from trauma occurs in a relational context, and the impacts of traumatic experiences that result in post-traumatic stress disorder (PTSD) go beyond the diagnosis itself. To fully understand a treatment for PTSD, understanding its impact on interpersonal, relational, and growth outcomes yields a more fulsome picture of the effects of the treatment. The current paper examines these secondary outcomes of a pilot trial of Cognitive Behavioral Conjoint Therapy (CBCT) for PTSD with MDMA. Six romantic dyads, where one partner had PTSD, undertook a course of treatment combining CBCT for PTSD with two MDMA psychotherapy sessions. Outcomes were assessed at mid-treatment, post-treatment, and 3- and 6-month follow-up. Both partners reported improvements in post-traumatic growth, relational support, and social intimacy. Partners reported reduced behavioral accommodation and conflict in the relationship, and patients with PTSD reported improved psychosocial functioning and empathic concern. These improvements were maintained throughout the follow-up period. These findings suggest that CBCT for PTSD with MDMA has significant effect on relational and growth outcomes in this pilot sample. Improvements in these domains is central to a holistic recovery from traumatic experiences, and lends support to the utility of treating PTSD dyadically.
Research Summary of 'Relational and Growth Outcomes Following Couples Therapy With MDMA for PTSD'
Introduction
Traumatic events affect not only individual functioning but also relationships, and social interactions play a central role in the development, maintenance, and recovery from post-traumatic stress disorder (PTSD). Previous work shows that PTSD commonly impairs interpersonal functioning and that negative social responses can worsen symptoms. Post-traumatic growth (positive psychological change following trauma) and relational outcomes are important domains for holistic recovery but have not been widely measured in trials of MDMA-assisted psychotherapy, nor have collateral reports from partners been collected in those individual MDMA studies. Wagner and colleagues report secondary relational and growth outcomes from a proof-of-concept pilot of Cognitive Behavioural Conjoint Therapy (CBCT) for PTSD combined with two MDMA-assisted psychotherapy sessions. The study aimed to examine interpersonal, relationship quality, and post-traumatic growth outcomes for both the person with PTSD and their partner across mid-treatment, post-treatment, and 3- and 6-month follow-up assessments, building on previously reported large reductions in PTSD symptoms from the same trial.
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Study Details
- Study Typeindividual
- Journal
- Compound
- Topics
- Authors
- APA Citation
Wagner, A. C., Liebman, R. E., Mithoefer, A. T., Mithoefer, M. C., & Monson, C. M. (2021). Relational and Growth Outcomes Following Couples Therapy With MDMA for PTSD. Frontiers in Psychiatry, 12. https://doi.org/10.3389/fpsyt.2021.702838
References (7)
Papers cited by this study that are also in Blossom
Greer, G. R. · Journal of Psychoactive Drugs (1986)
Wagner, A. C., Mithoefer, M. C., Mithoefer, A. T. et al. · Journal of Psychoactive Drugs (2019)
Feduccia, A. A., Mithoefer, M. C. · Progress in Neuro-Psychopharmacology and Biological Psychiatry (2018)
Mithoefer, M. C., Feduccia, A. A., Jerome, L. et al. · Psychopharmacology (2019)
Mithoefer, M. C., Wagner, M. T., Mithoefer, A. T. et al. · Journal of Psychopharmacology (2012)
Gorman, I., Belser, A. B., Jerome, L. et al. · Journal of Traumatic Stress (2020)
Monson, C. M., Wagner, A. C., Mithoefer, A. T. et al. · European Journal of Psychotraumatology (2020)
Cited By (6)
Papers in Blossom that reference this study
O'Donnell, K., Okano, L., Alpert, M. et al. · Frontiers in Psychology (2024)
Zeifman, R. J., Kettner, H., Ross, S. et al. · European Journal of Psychotraumatology (2024)
Bouso, J. C., Révész, D., Ona, G. et al. · Scientific Reports (2023)
Peterson, A., Largent, E. A., Sisti, D. et al. · AJOB Neuroscience (2022)
Traynor, J. M., Roberts, D. E., Ross, S. et al. · Focus (2022)
Cavarra, M., Falzone, A., Ramaekers, J. G. et al. · Frontiers in Psychology (2022)
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