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Psychedelic Research Links December 2022

Published on 12/5/2022

This is all the other psychedelic research that came out in December 2022. These papers don’t (yet) have their own page in our database.

You can find all interesting papers in our Papers Database.

Related Papers

In Rodents

  • Psychedelic-Induced Serotonin 2A Receptor Downregulation Does Not Predict Swim Stress Coping in Mice (in mice, “When DOI was administered 1 day before the forced swim test, a low dose (0.2 mg/kg i.p.) unexpectedly increased immobility while a high dose (2 mg/kg i.p.) had no significant effect on immobility. Nevertheless, DOI evoked a dose-dependent decrease in 5-HT2A levels in the mPFC of mice previously exposed to swim stress. Our findings do not support the hypothesis that the downregulation of 5-HT2A receptors in the mPFC contributes to the antidepressant-like properties of serotoninergic psychedelics.“)
  • Effect of psilocybin on decision-making and motivation in the healthy rat (in rats, “Results from this study demonstrated that exposure to 1 mg/kg psilocybin did not affect decision-making in the probability and delay discounting tasks and did not reduce response rates in the progressive ratio task. However, psilocybin treatment did cause the expected increase in head twitch responses in both male and female rats, demonstrating that the drug was delivered at a pharmacologically relevant dosage.“)
  • Astroglial mediation of fast-acting antidepressant effect in zebrafish (in zebrafish!, “…ketamine exerts its antidepressant effects by inhibiting an astroglial population that integrates futility and changes behavioral state. Astroglia play central roles in modulating circuit dynamics, and our work argues that targeting astroglial signaling may be a fruitful strategy for designing new rapid-acting antidepressants.”)

Chemistry

  • Phylogenomics of the psychoactive mushroom genus Psilocybe and evolution of the psilocybin biosynthetic gene cluster (“Molecular clock analysis suggests the stem lineage arose ∼66 mya and diversified ∼53 mya. We also show that psilocybin biosynthesis first arose in Psilocybe, with 4–5 possible horizontal transfers to other mushrooms between 40 and 22 mya. Moreover, predicted orthologs of the psilocybin biosynthetic genes revealed two distinct gene orders within the cluster that corresponds to a deep split within the genus, possibly consistent with the independent acquisition of the cluster.”)

Perspectives/Opinions

Reviews

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Psychedelic Research Links December 2022 - Blossom | Blossom