Psychedelics Research Links January 2022

This is all the other psychedelic research that comes out in January 2022. These papers don’t (yet) have their own page in our database.

This page will be updated (almost) every day.

You can find all interesting papers in our Papers Database.

Related Papers

Use CTRL/CMD+F to quickly search if anything relevant for you has been published this month.

• In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5-HT2AR (reveiw, molecular techniques to characterize 5HT-2A receptor agonsits)

• The potential of psychedelic medicine – A personal account (Addiction specialist and founder of the Haight Ashbury Free Clinic, David Smith MD, gives his thoughts on psychedelic medicine)

• Ketamine self-medication in a patient with autism spectrum disorder and comorbid treatment-resistant depression (case study, Dutch, successful self-medication with ketamine)

• A long trip into the universe: Psychedelics and space travel (the potential benefits of astronauts using psychedelics)

• Comparison of the efficacy of intranasal ketamine versus intravenous ketorolac on acute non-traumatic headaches: a randomized double-blind clinical trial (ketamine is more effective than ketorolac for acute headaches)

• Mental health conditions and receipt of mental health care by illicit lysergic acid diethylamide (LSD) use status among young adults in the United States (survey, those who have used LSD have “elevated prevalence of mental health conditions and are less likely to receive prescription medications for mental health care and overall mental health care“)

• Eating disorders and subsequent risk of substance use disorders involving illicit drugs: a Danish nationwide register-based cohort study (retrospective cohort study using, eating disorders and risk of substance abuse)

• Tabernaemontana arborea and ibogaine induce paroxysmal EEG activity in freely moving mice: involvement of serotonin 5-HT1A receptors (rodent study, evaluating the effects of Tabernaemontana species, including iobagine, on the central nervous system)

• Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD (rodent study, investigating the potenital of DMT and pharmahuasca to reduce reactive oxygen speices and alter gene expression)

• Prevention and treatment of PTSD: the current evidence base (review, different therapeis for PTSD)

• Huxley via Schelling: Toward an Asthetic Approach to Psychedelic Experience (commentary, the failure to address the often ineffable psychedelic experience is realted to the methods of current scientific research)

• Effects of Psychedelic Use on Racial Trauma Symptoms and Ethnic Identity among Asians in North America (survey, psychedelics can help to alleviate symtpoms of racial trauma in an Asian cohort in North America)

• Hallucinogens, alcohol and shifting leadership strategies in the ancient Peruvian Andes (commentary, how politices in the ancient Peruvian Andes were entangled with alchol and psychedelics)

• Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression (analysis of patients blood following a single keamine infusion)

• Racemic Ketamine as an Alternative to Electroconvulsive Therapy for Unipolar Depression: A Randomized, Open-Label, Non-Inferiority Trial (KetECT) (RCT, racemic ketamine for unipolar depression)

• Assessing the risk–benefit profile of classical psychedelics: a clinical review of second-wave psychedelic research (review, risk-benefit profile of psychdelics)

• Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism (neuroimaging study)

• A Trip Through Employment Law: Protecting Therapeutic Psilocybin Users in the Workplace (makes the case for protecting psilocybin users in the workplace in light of legalization in some US states)

• Caffeine and MDMA (ecstasy) exacerbate ER stress triggered by hyperthermia (in vitro, effects of caffine and MDMA on endoplasmic recticulum stress (ER))

• Analysis of recreational psychedelic substance use experiences classified by substance (quantiative lingustic analysis, examining word frequencies related to various psychological states and processes and semantic proximity to psychedelic and mystical experience scales)

• The therapeutic potential of psychedelic substances in Hospice and Palliative Care (editorial, the use of psychedelics in palliative care)

• Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system (fMRI and PET in healthy subjects, clarifying the association between behavioural inhibition systems and 5-H2TA receptor availability and specificity)

• Development of a Liquid Chromatography Mass Spectrometry Method for the Determination of Tryptamines in Whole Blood (masters thesis)

• Rapid cycling bipolar disorder: Literature review on pharmacological treatment illustrated by a case report on ketamine (review using a case report using ketamine for bipolar disorder)

• The Rapid Rise in Investment in Psychedelics—Cart Before the Horse (opinion piece)

• Shedding Light on Classic Psychedelics and Self-Harm (commentary)

• Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry (review, includes trials exploring nitrous oxide, ayahuasca and psilocybin)

• Philosophy and classic psychedelics: A review of some emerging themes (review, “an overview of four emerging lines of research at the intersection of academic philosophy and psychedelic science”

• Psychedelic-assisted psychotherapy for the treatment of major depression: a synthesis of phenomenological explanations (using phenomenological literature to explain the therapeutic potential of psychedelic experiences)

• Behavioral and neurochemical effects of novel N-Benzyl-2-phenylethylamine derivatives in adult zebrafish (testing derivatives of N-Benzyl-2-phenylethylamine derivatives in zebra fish)

• Intravenous Esketamine Leads to an Increase in Impulsive and Suicidal Behavior in a Patient with Recurrent Major Depression and Borderline Personality Disorder (case study)

• Crystallographic hallucinations (a response to Sherwood et al’s study using crystallographic techniques to explore psilocybin polymorphs)

• Comment and Response: (Lugo-Radillo & Cortez-Lopez, 2020) Long-Term Amelioration of OCD Symptoms in a Patient with Chronic Consumption of Psilocybin-Containing Mushrooms (letter to the editor, case studies with psychedelics should no longer be the focus of journals)

• Iboga Inspired N-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents (investigation of iboga alkaoids and their potential to stimulate the release of glial cell line-derived neurotrophic factor (GDNF))

• Structure-based discovery of nonhallucinogenic psychedelic analogs (“a solid foundation for the structure-based design of safe and effective nonhallucinogenic psychedelic analogs with therapeutic effects”)

• Ketamine as a therapeutic agent for depression and pain: mechanisms and evidence (review)

• The age of psychedelics (opinion, the current state and future of psychedelic medicine)

• Trip or Treat: Psychedelic Drug Reform in California (reforming psychedelic drug policy in California)

• Toward a Neurobiological Explanation of Mystical Experience (explaining the mystical experience)

• No party, no drugs? Use of stimulants, dissociative drugs, and GHB/GBL during the early COVID-19 pandemic (survey, drug use over the pandemic)