What happened in psychedelic research in 1966

Week of 1 August 1966

• PaperPsychedelic Agents in Creative Problem-Solving: A Pilot Study1 Aug

  This pilot study of 27 professionally employed men found that a single, carefully structured psychedelic session with LSD-25 or mescaline appeared to facilitate creative problem‑solving, especially during the “illumination” phase. Subjective reports, creativity tests and assessments of solution utility suggested that enhanced creative ability persisted for some participants for several weeks afterwards.

  LSDMescalineCreativitySet & Setting

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Week of 27 December 1965

• StartedSingle Oral Lysergide (LSD 500 µg) in Inpatient Alcoholic Rehabilitation: Controlled Evaluation with Schizophrenic Sub-Anal… (lsd)1 Jan

  This unregistered trial (n=75) was a partially randomised, placebo-controlled evaluation of a single 500 µg oral dose of LSD for alcohol use disorder in an inpatient rehabilitation setting, which found higher abstinence rates in non-schizophrenic participants at one year.

  LSD

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• StartedLSD Treatment for Anticipatory Anxiety in Pre-Terminal Cancer Patients: An Open-Label Clinical Series (Kast 1967) (lsd)1 Jan

  This unregistered trial (n=128) was an open-label clinical series of single-dose LSD for anticipatory anxiety and pain in pre-terminal cancer patients, which demonstrated a reduction in psychological distress and improved sleep patterns.

  LSD

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• StartedA clinical study of LSD treatment in alcoholism (lsd)1 Jan

  Randomized controlled three-year investigation comparing three LSD treatment conditions (hypnodelic, psychedelic, and drug-alone) against a milieu therapy control in 176 male alcoholic inpatients at Mendota State Hospital, Wisconsin. All groups improved significantly across all follow-up periods; no LSD condition outperformed the control.

  LSD

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