What happened in psychedelic research in 1986

Week of 29 September 1986

• PaperThe psychological and physiological effects of MDMA on normal volunteers1 Oct

  This early study (1986) of the effects of MDMA suggests that MDMA exerts predictable transient psychological effects and shows no major toxicity. However, the author cautiously concludes that the evidence is insufficient to make definitive judgments.

  MDMAPersonality & Trait Factors

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• PaperSubjective reports of the effects of MDMA in a clinical setting1 Oct

  This open-label study (n=29) is a summary report of the first people administered MDMA (75-150mg) in a clinical setting. The data is limited to phenomenological descriptions obtained from therapist observations and subject experiences before, during, and after the sessions.

  MDMAEquity and Ethics

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• PaperMDMA and Human Sexual Function1 Oct

  This retrospective survey study (n=26) examined self-reported sexuality under the influence of MDMA (≈125mg) compared to sober state and found that it increased emotional closeness, enhanced receptivity to being sexual, and was often chosen as a sexual enhancer by the participants, but it did not stimulate the desire to initiate sex and decreased erectile ability in 46% of the male participants.

  MDMA

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• PaperDifferences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens1 Oct

  This seminal paper (1986) introduces the classification 'entactogens' for MDMA and compounds with similar psychopharmacological action.

  MDMAAnxiety DisordersMedicinal Chemistry & Drug DevelopmentInterpersonal Functioning & Social Connectedness

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